Eukaryotic chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity

Research output: Contribution to journalArticle

Abstract

Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal physiology and in the pathogenesis of many diseases. Chemotactic cells display motility, directional sensing, and polarity. Motility refers to the random extension of pseudopodia, which may be driven by spontaneous actin waves that propagate through the cytoskeleton. Directional sensing is mediated by a system that detects temporal and spatial stimuli and biases motility toward the gradient. Polarity gives cells morphologically and functionally distinct leading and lagging edges by relocating proteins or their activities selectively to the poles. By exploiting the genetic advantages of Dictyostelium, investigators are working out the complex network of interactions between the proteins that have been implicated in the chemotactic processes of motility, directional sensing, and polarity.

Original languageEnglish (US)
Pages (from-to)265-289
Number of pages25
JournalAnnual Review of Biophysics
Volume39
Issue number1
DOIs
StatePublished - Jun 9 2010

Fingerprint

Chemotaxis
Cell Movement
Proteins
Protein Interaction Maps
Cell Polarity
Pseudopodia
Dictyostelium
Physiology
Complex networks
Cytoskeleton
Actins
Poles
Cells
Research Personnel

Keywords

  • Adaptation
  • Dictyostelium
  • Local Excitation Global Inhibition (LEGI) model
  • Protein localization

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Structural Biology
  • Bioengineering

Cite this

Eukaryotic chemotaxis : A network of signaling pathways controls motility, directional sensing, and polarity. / Swaney, Kristen F.; Huang, Chuan Hsiang; Devreotes, Peter N.

In: Annual Review of Biophysics, Vol. 39, No. 1, 09.06.2010, p. 265-289.

Research output: Contribution to journalArticle

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