TY - JOUR
T1 - Etravirine and Rilpivirine Drug Resistance among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India
AU - Saravanan, Shanmugam
AU - Kausalya, Bagavathi
AU - Gomathi, Selvamurthi
AU - Sivamalar, Sathasivam
AU - Pachamuthu, Balakrishnan
AU - Selvamuthu, Poongulali
AU - Pradeep, Amrose
AU - Sunil, Solomon
AU - Mothi, Sarvode N.
AU - Smith, Davey M.
AU - Kantor, Rami
N1 - Publisher Copyright:
© 2017, Mary Ann Liebert, Inc.
PY - 2017/6
Y1 - 2017/6
N2 - We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included first-generation non-nucleoside RT inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second-generation non-nucleoside RT inhibitors drugs Etravirine (ETR) and Rilpivirine, respectively. These cross-resistance mutations may compromise future NNRTI-based regimens, especially in resource-limited settings. To complement these investigations, we also analyzed the sequences in Stanford database, Monogram weighted score, and DUET weighted score algorithms for ETR susceptibility and found almost perfect agreement between the three algorithms in predicting ETR susceptibility from genotypic data.
AB - We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included first-generation non-nucleoside RT inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second-generation non-nucleoside RT inhibitors drugs Etravirine (ETR) and Rilpivirine, respectively. These cross-resistance mutations may compromise future NNRTI-based regimens, especially in resource-limited settings. To complement these investigations, we also analyzed the sequences in Stanford database, Monogram weighted score, and DUET weighted score algorithms for ETR susceptibility and found almost perfect agreement between the three algorithms in predicting ETR susceptibility from genotypic data.
KW - HIV drug resistance
KW - HIV drug resistance in South India
KW - HIV in children
KW - etravirine
KW - etravirine resistance in children
KW - rilpivirine
KW - subtype C resistance
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U2 - 10.1089/aid.2016.0133
DO - 10.1089/aid.2016.0133
M3 - Article
C2 - 27869478
AN - SCOPUS:85020432820
SN - 0889-2229
VL - 33
SP - 567
EP - 574
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 6
ER -