Etravirine and Rilpivirine Drug Resistance among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India

Shanmugam Saravanan, Bagavathi Kausalya, Selvamurthi Gomathi, Sathasivam Sivamalar, Balakrishnan Pachamuthu, Poongulali Selvamuthu, Amrose Pradeep, Sunil Solomon, Sarvode N. Mothi, Davey M. Smith, Rami Kantor

Research output: Contribution to journalArticle

Abstract

We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included first-generation non-nucleoside RT inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second-generation non-nucleoside RT inhibitors drugs Etravirine (ETR) and Rilpivirine, respectively. These cross-resistance mutations may compromise future NNRTI-based regimens, especially in resource-limited settings. To complement these investigations, we also analyzed the sequences in Stanford database, Monogram weighted score, and DUET weighted score algorithms for ETR susceptibility and found almost perfect agreement between the three algorithms in predicting ETR susceptibility from genotypic data.

Original languageEnglish (US)
Pages (from-to)567-574
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • etravirine
  • etravirine resistance in children
  • HIV drug resistance
  • HIV drug resistance in South India
  • HIV in children
  • rilpivirine
  • subtype C resistance

ASJC Scopus subject areas

  • Immunology
  • Infectious Diseases
  • Virology

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    Saravanan, S., Kausalya, B., Gomathi, S., Sivamalar, S., Pachamuthu, B., Selvamuthu, P., Pradeep, A., Solomon, S., Mothi, S. N., Smith, D. M., & Kantor, R. (2017). Etravirine and Rilpivirine Drug Resistance among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India. AIDS Research and Human Retroviruses, 33(6), 567-574. https://doi.org/10.1089/aid.2016.0133