Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities

Kristen J. Mertz; David Trees; William C. Levine; Joel S. Lewis; Billy Litchfield; Kevin S. Pettus; Stephen A. Morse; Michael E. St Louis; Judith B. Weiss; Jane Schwebke; James Dickes; Romina Kee; James Reynolds; Don Hutcheson; Donata Green; Irene Dyer; Gary A. Richwald; James Novotny; Isaac Weisfuse; Martin Goldberg; Judith A. O'Donnell; Richard Knaup

doi:10.1086/314502

Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities

Kristen J. Mertz, David Trees, William C. Levine, Joel S. Lewis, Billy Litchfield, Kevin S. Pettus, Stephen A. Morse, Michael E. St Louis, Judith B. Weiss, Jane Schwebke, James Dickes, Romina Kee, James Reynolds, Don Hutcheson, Donata Green, Irene Dyer, Gary A. Richwald, James Novotny, Isaac Weisfuse, Martin GoldbergJudith A. O'Donnell, Richard Knaup

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125 Scopus citations

Abstract

To determine the etiology of genital ulcers and to assess the prevalence of human immunodeficiency virus (HIV) infection in ulcer patients in 10 US cities, ulcer and serum specimens were collected from ~50 ulcer patients at a sexually transmitted disease clinic in each city. Ulcer specimens were tested using a multiplex polymerase chain reaction assay to detect Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV); sera were tested for antibody to HIV. H. ducreyi was detected in ulcer specimens from patients in Memphis (20% of specimens) and Chicago (12%). T. pallidum was detected in ulcer specimens from every city except Los Angeles (median, 9% of specimens; range, 0%-46%). HSV was detected in ≥50% of specimens from all cities except Memphis (42%). HIV seroprevalence in ulcer patients was 6% (range by city, 0%-18%). These data suggest that chancroid is prevalent in some US cities and that persons with genital ulcers should be a focus of HIV prevention activities.

Original language	English (US)
Pages (from-to)	1795-1798
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	178
Issue number	6
DOIs	https://doi.org/10.1086/314502
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Mertz, K. J., Trees, D., Levine, W. C., Lewis, J. S., Litchfield, B., Pettus, K. S., Morse, S. A., St Louis, M. E., Weiss, J. B., Schwebke, J., Dickes, J., Kee, R., Reynolds, J., Hutcheson, D., Green, D., Dyer, I., Richwald, G. A., Novotny, J., Weisfuse, I., ... Knaup, R. (1998). Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities. Journal of Infectious Diseases, 178(6), 1795-1798. https://doi.org/10.1086/314502

Mertz, KJ, Trees, D, Levine, WC, Lewis, JS, Litchfield, B, Pettus, KS, Morse, SA, St Louis, ME, Weiss, JB, Schwebke, J, Dickes, J, Kee, R, Reynolds, J, Hutcheson, D, Green, D, Dyer, I, Richwald, GA, Novotny, J, Weisfuse, I, Goldberg, M, O'Donnell, JA & Knaup, R 1998, 'Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities', Journal of Infectious Diseases, vol. 178, no. 6, pp. 1795-1798. https://doi.org/10.1086/314502

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title = "Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities",

abstract = "To determine the etiology of genital ulcers and to assess the prevalence of human immunodeficiency virus (HIV) infection in ulcer patients in 10 US cities, ulcer and serum specimens were collected from ~50 ulcer patients at a sexually transmitted disease clinic in each city. Ulcer specimens were tested using a multiplex polymerase chain reaction assay to detect Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV); sera were tested for antibody to HIV. H. ducreyi was detected in ulcer specimens from patients in Memphis (20% of specimens) and Chicago (12%). T. pallidum was detected in ulcer specimens from every city except Los Angeles (median, 9% of specimens; range, 0%-46%). HSV was detected in ≥50% of specimens from all cities except Memphis (42%). HIV seroprevalence in ulcer patients was 6% (range by city, 0%-18%). These data suggest that chancroid is prevalent in some US cities and that persons with genital ulcers should be a focus of HIV prevention activities.",

author = "Mertz, {Kristen J.} and David Trees and Levine, {William C.} and Lewis, {Joel S.} and Billy Litchfield and Pettus, {Kevin S.} and Morse, {Stephen A.} and {St Louis}, {Michael E.} and Weiss, {Judith B.} and Jane Schwebke and James Dickes and Romina Kee and James Reynolds and Don Hutcheson and Donata Green and Irene Dyer and Richwald, {Gary A.} and James Novotny and Isaac Weisfuse and Martin Goldberg and O'Donnell, {Judith A.} and Richard Knaup",

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AU - O'Donnell, Judith A.

AU - Knaup, Richard

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Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities

Abstract

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