Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities

Kristen J. Mertz, David Trees, William C. Levine, Joel S. Lewis, Billy Litchfield, Kevin S. Pettus, Stephen A. Morse, Michael E. St Louis, Judith B. Weiss, Jane Schwebke, James Dickes, Romina Kee, James Reynolds, Don Hutcheson, Donata Green, Irene Dyer, Gary A. Richwald, James Novotny, Isaac Weisfuse, Martin GoldbergJudith A. O'Donnell, Richard Knaup

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the etiology of genital ulcers and to assess the prevalence of human immunodeficiency virus (HIV) infection in ulcer patients in 10 US cities, ulcer and serum specimens were collected from ~50 ulcer patients at a sexually transmitted disease clinic in each city. Ulcer specimens were tested using a multiplex polymerase chain reaction assay to detect Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus (HSV); sera were tested for antibody to HIV. H. ducreyi was detected in ulcer specimens from patients in Memphis (20% of specimens) and Chicago (12%). T. pallidum was detected in ulcer specimens from every city except Los Angeles (median, 9% of specimens; range, 0%-46%). HSV was detected in ≥50% of specimens from all cities except Memphis (42%). HIV seroprevalence in ulcer patients was 6% (range by city, 0%-18%). These data suggest that chancroid is prevalent in some US cities and that persons with genital ulcers should be a focus of HIV prevention activities.

Original languageEnglish (US)
Pages (from-to)1795-1798
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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