Abstract
Despite rotavirus vaccination, diarrhea remains a leading cause of child mortality. We collected stool specimens from 684 children <5 years of age hospitalized with diarrhea (cases) and 527 asymptomatic community controls for 4 years after rotavirus vaccine introduction in Malawi. Specimens were tested for 29 pathogens, using polymerase chain reaction analysis. Three or more pathogens were detected in 71% of cases and 48% of controls. Pathogens significantly associated with diarrhea included rotavirus (in 34.7% of cases and 1.5% of controls), enteric adenovirus (in 29.1% and 2.7%, respectively), Cryptosporidium (in 27.8% and 8.2%, respectively), heat-stable enterotoxin-producing Escherichia coli (in 21.2% and 8.5%, respectively), typical enteropathogenic E. coli (in 18.0% and 8.3%, respectively), and Shigella/enteroinvasive E. coli (in 15.8% and 5.7%, respectively). Additional interventions are required to prevent diarrhea due to rotavirus and other common causal pathogens.
Original language | English (US) |
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Article number | jiz084 |
Pages (from-to) | 213-218 |
Number of pages | 6 |
Journal | Journal of Infectious Diseases |
Volume | 220 |
Issue number | 2 |
DOIs | |
State | Published - Jun 19 2019 |
Keywords
- Gastroenteritis
- Malawi
- PCR
- case-control
- children
- diarrhea
- rotavirus
ASJC Scopus subject areas
- General Medicine