Etiology

Sonya U. Steele, Ellen M. Mowry

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple sclerosis (MS) is a leading cause of neurological disability in young adults. Although much remains to be understood about its etiology, converging evidence suggests that it is a complex disease that emerges from an abnormal autoimmune response in genetically susceptible individuals after specific environmental exposures. Association studies have identified several single nucleotide polymorphism susceptibility loci in addition to the well-established allele HLA-DRB1*1501. Proposed environmental risk factors include infections, smoking, and vitamin D deficiency. Here, we review the strongest candidate etiologic factors in MS.

Original languageEnglish (US)
Title of host publicationMultiple Sclerosis and CNS Inflammatory Disorders
PublisherWiley-Blackwell
Pages1-9
Number of pages9
ISBN (Electronic)9781118298633
ISBN (Print)9780470673881
DOIs
StatePublished - Aug 25 2014

Keywords

  • Environment
  • Epidemiology
  • Etiology
  • Gender
  • Genetics
  • HLA
  • Latitude
  • Parent-of-origin effect
  • Risk factors
  • Virology

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Steele, S. U., & Mowry, E. M. (2014). Etiology. In Multiple Sclerosis and CNS Inflammatory Disorders (pp. 1-9). Wiley-Blackwell. https://doi.org/10.1002/9781118298633.ch1