TY - JOUR
T1 - Etiologies of bacterial meningitis in bangladesh
T2 - Results from a hospital-based study
AU - Gurley, Emily S.
AU - Hossain, M. Jahangir
AU - Montgomery, Susan P.
AU - Petersen, Lyle R.
AU - Sejvar, James J.
AU - Mayer, Leonard W.
AU - Whitney, Anne
AU - Dull, Peter
AU - Nahar, Nazmun
AU - Uddin, A. K.M.Rafique
AU - Rahman, M. Ekhlasur
AU - Ekram, A. R.M.Saifuddin
AU - Luby, Stephen P.
AU - Breiman, Robert F.
PY - 2009/9
Y1 - 2009/9
N2 - We conducted a study at four hospitals from June 2003 to July 2005 to investigate the etiologies of bacterial meningitis in Bangladesh. A total of 2,609 patients met the clinical case definition, and 766 had cerebrospinal fluid tested by at least one of the following methods: latex agglutination, 16S rRNA gene sequencing, or real-time polymerase chain reaction for Neisseria meningitidis A and C, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib); culture results were noted from patient records. In total, 189 patients (24%) of those tested, representing all age groups, were diagnosed with bacterial meningitis; 136 (18%) had meningococcal, 23 (3%) had pneumococcal, and 25 (3%) had Hib infection. Twenty percent of patients with Hib meningitis (5/25) were > 15 years old. Case-fatality ratios were 10% for N. meningitidis, 22% for S. pneumoniae, and 24% for Hib. Bacterial meningitis from vaccine-preventable pathogens causes significant morbidity and mortality in Bangladesh in adults and children.
AB - We conducted a study at four hospitals from June 2003 to July 2005 to investigate the etiologies of bacterial meningitis in Bangladesh. A total of 2,609 patients met the clinical case definition, and 766 had cerebrospinal fluid tested by at least one of the following methods: latex agglutination, 16S rRNA gene sequencing, or real-time polymerase chain reaction for Neisseria meningitidis A and C, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib); culture results were noted from patient records. In total, 189 patients (24%) of those tested, representing all age groups, were diagnosed with bacterial meningitis; 136 (18%) had meningococcal, 23 (3%) had pneumococcal, and 25 (3%) had Hib infection. Twenty percent of patients with Hib meningitis (5/25) were > 15 years old. Case-fatality ratios were 10% for N. meningitidis, 22% for S. pneumoniae, and 24% for Hib. Bacterial meningitis from vaccine-preventable pathogens causes significant morbidity and mortality in Bangladesh in adults and children.
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U2 - 10.4269/ajtmh.2009.81.475
DO - 10.4269/ajtmh.2009.81.475
M3 - Article
C2 - 19706918
AN - SCOPUS:69249177356
SN - 0002-9637
VL - 81
SP - 475
EP - 483
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -