Etiological heterogeneity in Hodgkin's disease: HLA linked and unlinked determinants of susceptibility independent of histological concordance

Aravinda Chakravarti, Susan L. Halloran, Sherri J. Bale, Margaret A. Tucker

Research output: Contribution to journalArticle

Abstract

Forty-one multiplex families, from published sources and new data from the National Cancer Institute, segregating for Hodgkin's disease and HLA, have been studied. A reanalysis of these data strongly suggests a recessive mode of inheritance for susceptibility to Hodgkin's disease. The HLA haplotype sharing data between affected relatives demonstrate that approximately 60% of cases in multiplex families are due to an HLA-linked susceptibility gene, the remaining 40% being due to other familial factors. The data clearly support the hypothesis of etiological heterogeneity for Hodgkin's disease, with both HLA-linked and HLA-unlinked factors being responsible. Finally, there is an increased concordance of histological types between affected relatives, but this concordance seems independent of HLA sharing.

Original languageEnglish (US)
Pages (from-to)407-415
Number of pages9
JournalGenetic epidemiology
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1986

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Keywords

  • HLA linkage
  • Hodgkin's disease
  • etiological heterogeneity
  • recessive susceptibility gene

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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