Etiologic heterogeneity of hyperapobetalipoproteinemia (hyperapoB): Results from segregation analysis in families with premature coronary artery disease

Suh Hang Hank Juo, Terri H. Beaty, Peter O. Kwiterovich

Research output: Contribution to journalArticle

Abstract

Hyperapobetalipoproteinemia (hyperapoB) is a common familial lipoprotein disorder associated with premature coronary artery disease (CAD). HyperapoB is characterized by an increased number of small, dense LDL particles. Patients with hyperapoB may be normotriglyceridemic (normoTG) or hypertriglyceridemic (hyperTG). We tested the hypothesis that a major locus controls the hyperapoB phenotype by using data from 1035 participants in 145 families enriched for premature CAD. Segregation analysis was conducted, and results suggest etiologic heterogeneity in these families. Families (n=55) with one or more hyperTG hyperapoB individuals strongly supported mendelian recessive inheritance of hyperapoB. Under this mendelian model, individuals with the high-risk genotype had a baseline risk of 0.78, but parental and spouse's hyperapoB phenotypes did influence the probability of displaying hyperapoB. Low-risk genotypes had virtually no risk of displaying hyperapoB. The other subgroup of families (n=72), in which all hyperapoB individuals were normoTG, did not show any clear pattern of inheritance. Eighteen families did not have any hyperapoB individual. In the 55 families with hyperTG hyperapoB, diabetes was more prevalent in hyperapoB individuals (18.3% of hyperTG hyperapoB individuals, 9.6% of normoTG hyperapoB individuals) than in normal individuals (4.9%). Both hyperTG hyperapoB and normoTG hyperapoB phenotypes were significant predictors for blood pressure in the 55 families, but not in the total population. These associations further suggest a link between hyperapoB and the small, dense LDL syndromes. This study successfully demonstrated mendelian inheritance of the hyperapoB phenotype and also suggested etiologic heterogeneity of hyperapoB.

Original languageEnglish (US)
Pages (from-to)2729-2736
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Volume17
Issue number11
DOIs
StatePublished - Jan 1 1997

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Keywords

  • Apolipoprotein B
  • Coronary artery disease
  • Etiologic heterogeneity
  • Familial combined hyperlipidemia
  • HyperapoB
  • Segregation analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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