Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

K. T. Kelsey; D. Ross; R. D. Traver; D. C. Christiani; Z. F. Zuo; M. R. Spitz; M. Wang; X. Xu; B. K. Lee; B. S. Schwartz; J. K. Wiencke

doi:10.1038/bjc.1997.474

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

K. T. Kelsey, D. Ross, R. D. Traver, D. C. Christiani, Z. F. Zuo, M. R. Spitz, M. Wang, X. Xu, B. K. Lee, B. S. Schwartz, J. K. Wiencke

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

The NAD(P)H quinone oxidoreductase (NQ01:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

Original language	English (US)
Pages (from-to)	852-854
Number of pages	3
Journal	British journal of cancer
Volume	76
Issue number	7
DOIs	https://doi.org/10.1038/bjc.1997.474
State	Published - 1997

Keywords

DT diaphorase
Ethnicity
NQ01
Polymorphism
Second cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/bjc.1997.474

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Kelsey, K. T., Ross, D., Traver, R. D., Christiani, D. C., Zuo, Z. F., Spitz, M. R., Wang, M., Xu, X., Lee, B. K., Schwartz, B. S., & Wiencke, J. K. (1997). Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. British journal of cancer, 76(7), 852-854. https://doi.org/10.1038/bjc.1997.474

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abstract = "The NAD(P)H quinone oxidoreductase (NQ01:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.",

keywords = "DT diaphorase, Ethnicity, NQ01, Polymorphism, Second cancer",

author = "Kelsey, {K. T.} and D. Ross and Traver, {R. D.} and Christiani, {D. C.} and Zuo, {Z. F.} and Spitz, {M. R.} and M. Wang and X. Xu and Lee, {B. K.} and Schwartz, {B. S.} and Wiencke, {J. K.}",

year = "1997",

doi = "10.1038/bjc.1997.474",

language = "English (US)",

volume = "76",

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AU - Ross, D.

AU - Traver, R. D.

AU - Christiani, D. C.

AU - Zuo, Z. F.

AU - Spitz, M. R.

AU - Wang, M.

AU - Xu, X.

AU - Lee, B. K.

AU - Schwartz, B. S.

AU - Wiencke, J. K.

PY - 1997

Y1 - 1997

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AB - The NAD(P)H quinone oxidoreductase (NQ01:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

KW - DT diaphorase

KW - Ethnicity

KW - NQ01

KW - Polymorphism

KW - Second cancer

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Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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