Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

K. T. Kelsey, D. Ross, R. D. Traver, D. C. Christiani, Z. F. Zuo, M. R. Spitz, M. Wang, X. Xu, B. K. Lee, B. S. Schwartz, J. K. Wiencke

Research output: Contribution to journalArticlepeer-review

Abstract

The NAD(P)H quinone oxidoreductase (NQ01:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

Original languageEnglish (US)
Pages (from-to)852-854
Number of pages3
JournalBritish journal of cancer
Volume76
Issue number7
DOIs
StatePublished - 1997

Keywords

  • DT diaphorase
  • Ethnicity
  • NQ01
  • Polymorphism
  • Second cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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