Ethnic differences in weight gain and diabetes risk: The Multiethnic Cohort Study

Y. Morimoto, S. M. Schembre, A. Steinbrecher, Eva Oakkar, I. Pagano, A. Grandinetti, L. N. Kolonel, G. Maskarinec

Research output: Contribution to journalArticle

Abstract

Aim: To improve our understanding of excess body weight and risk for diabetes type 2, the study examined the influence of weight change in the Hawaii component, including 78,006 Caucasians, Japanese Americans and Native Hawaiians, of the Multiethnic Cohort Study. Methods: Participants aged 58.5 ± 9.2 years completed a questionnaire at cohort entry (Qx1), including weight at age 21, and a follow-up questionnaire 5. years later (Qx2). After 14 years of follow-up, 8892 incident diabetes cases were identified through self-reports or linkups with the major health plans in Hawaii. Cox regression analysis was applied, stratified by age and adjusted for confounders, to estimate hazard ratios (HRs). Results: The mean weight gain from age 21 to Qx1 was 10.5 ± 11.0. kg and, between Qx1 and Qx2, 0.8 ± 5.6. kg. Diabetes risk showed a significant dose-response relationship with weight gain from age 21 (P<0.0001). The respective HRs for a weight gain of 5-10. kg and greater or equal to 25. kg were 1.8 (95% CI: 1.7-2.0) and 7.7 (95% CI: 7.1-8.4), while weight loss of greater than 5. kg significantly reduced diabetes risk (HR = 0.7; 95% CI: 0.6-0.9). The interaction term of weight change since age 21 with ethnicity was also highly significant (P<0.0001). Compared with stable-weight Caucasians, the adverse effects of weight gain were more pronounced in those of Japanese and Native Hawaiian descent. Weight change between Qx1 and Qx2 conferred a smaller risk. Conclusion: These findings support the current public-health recommendations for weight control and particularly among ethnic groups at high risk for diabetes.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalDiabetes and Metabolism
Volume37
Issue number3
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Weight Gain
Cohort Studies
Weights and Measures
Oceanic Ancestry Group
Asian Americans
Ethnic Groups
Self Report
Type 2 Diabetes Mellitus
Weight Loss
Public Health
Odds Ratio
Body Weight
Regression Analysis
Health
Surveys and Questionnaires

Keywords

  • BMI
  • Epidemiology
  • Ethnicity
  • Hawaï
  • Incidence
  • Longitudinal study
  • Obesity
  • Prospective studies
  • Type 2 diabetes
  • Weight gain

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Morimoto, Y., Schembre, S. M., Steinbrecher, A., Oakkar, E., Pagano, I., Grandinetti, A., ... Maskarinec, G. (2011). Ethnic differences in weight gain and diabetes risk: The Multiethnic Cohort Study. Diabetes and Metabolism, 37(3), 230-236. https://doi.org/10.1016/j.diabet.2010.10.005

Ethnic differences in weight gain and diabetes risk : The Multiethnic Cohort Study. / Morimoto, Y.; Schembre, S. M.; Steinbrecher, A.; Oakkar, Eva; Pagano, I.; Grandinetti, A.; Kolonel, L. N.; Maskarinec, G.

In: Diabetes and Metabolism, Vol. 37, No. 3, 06.2011, p. 230-236.

Research output: Contribution to journalArticle

Morimoto, Y, Schembre, SM, Steinbrecher, A, Oakkar, E, Pagano, I, Grandinetti, A, Kolonel, LN & Maskarinec, G 2011, 'Ethnic differences in weight gain and diabetes risk: The Multiethnic Cohort Study', Diabetes and Metabolism, vol. 37, no. 3, pp. 230-236. https://doi.org/10.1016/j.diabet.2010.10.005
Morimoto Y, Schembre SM, Steinbrecher A, Oakkar E, Pagano I, Grandinetti A et al. Ethnic differences in weight gain and diabetes risk: The Multiethnic Cohort Study. Diabetes and Metabolism. 2011 Jun;37(3):230-236. https://doi.org/10.1016/j.diabet.2010.10.005
Morimoto, Y. ; Schembre, S. M. ; Steinbrecher, A. ; Oakkar, Eva ; Pagano, I. ; Grandinetti, A. ; Kolonel, L. N. ; Maskarinec, G. / Ethnic differences in weight gain and diabetes risk : The Multiethnic Cohort Study. In: Diabetes and Metabolism. 2011 ; Vol. 37, No. 3. pp. 230-236.
@article{124213af35f94b4b8e6736609ae4d7b0,
title = "Ethnic differences in weight gain and diabetes risk: The Multiethnic Cohort Study",
abstract = "Aim: To improve our understanding of excess body weight and risk for diabetes type 2, the study examined the influence of weight change in the Hawaii component, including 78,006 Caucasians, Japanese Americans and Native Hawaiians, of the Multiethnic Cohort Study. Methods: Participants aged 58.5 ± 9.2 years completed a questionnaire at cohort entry (Qx1), including weight at age 21, and a follow-up questionnaire 5. years later (Qx2). After 14 years of follow-up, 8892 incident diabetes cases were identified through self-reports or linkups with the major health plans in Hawaii. Cox regression analysis was applied, stratified by age and adjusted for confounders, to estimate hazard ratios (HRs). Results: The mean weight gain from age 21 to Qx1 was 10.5 ± 11.0. kg and, between Qx1 and Qx2, 0.8 ± 5.6. kg. Diabetes risk showed a significant dose-response relationship with weight gain from age 21 (P<0.0001). The respective HRs for a weight gain of 5-10. kg and greater or equal to 25. kg were 1.8 (95{\%} CI: 1.7-2.0) and 7.7 (95{\%} CI: 7.1-8.4), while weight loss of greater than 5. kg significantly reduced diabetes risk (HR = 0.7; 95{\%} CI: 0.6-0.9). The interaction term of weight change since age 21 with ethnicity was also highly significant (P<0.0001). Compared with stable-weight Caucasians, the adverse effects of weight gain were more pronounced in those of Japanese and Native Hawaiian descent. Weight change between Qx1 and Qx2 conferred a smaller risk. Conclusion: These findings support the current public-health recommendations for weight control and particularly among ethnic groups at high risk for diabetes.",
keywords = "BMI, Epidemiology, Ethnicity, Hawa{\"i}, Incidence, Longitudinal study, Obesity, Prospective studies, Type 2 diabetes, Weight gain",
author = "Y. Morimoto and Schembre, {S. M.} and A. Steinbrecher and Eva Oakkar and I. Pagano and A. Grandinetti and Kolonel, {L. N.} and G. Maskarinec",
year = "2011",
month = "6",
doi = "10.1016/j.diabet.2010.10.005",
language = "English (US)",
volume = "37",
pages = "230--236",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "3",

}

TY - JOUR

T1 - Ethnic differences in weight gain and diabetes risk

T2 - The Multiethnic Cohort Study

AU - Morimoto, Y.

AU - Schembre, S. M.

AU - Steinbrecher, A.

AU - Oakkar, Eva

AU - Pagano, I.

AU - Grandinetti, A.

AU - Kolonel, L. N.

AU - Maskarinec, G.

PY - 2011/6

Y1 - 2011/6

N2 - Aim: To improve our understanding of excess body weight and risk for diabetes type 2, the study examined the influence of weight change in the Hawaii component, including 78,006 Caucasians, Japanese Americans and Native Hawaiians, of the Multiethnic Cohort Study. Methods: Participants aged 58.5 ± 9.2 years completed a questionnaire at cohort entry (Qx1), including weight at age 21, and a follow-up questionnaire 5. years later (Qx2). After 14 years of follow-up, 8892 incident diabetes cases were identified through self-reports or linkups with the major health plans in Hawaii. Cox regression analysis was applied, stratified by age and adjusted for confounders, to estimate hazard ratios (HRs). Results: The mean weight gain from age 21 to Qx1 was 10.5 ± 11.0. kg and, between Qx1 and Qx2, 0.8 ± 5.6. kg. Diabetes risk showed a significant dose-response relationship with weight gain from age 21 (P<0.0001). The respective HRs for a weight gain of 5-10. kg and greater or equal to 25. kg were 1.8 (95% CI: 1.7-2.0) and 7.7 (95% CI: 7.1-8.4), while weight loss of greater than 5. kg significantly reduced diabetes risk (HR = 0.7; 95% CI: 0.6-0.9). The interaction term of weight change since age 21 with ethnicity was also highly significant (P<0.0001). Compared with stable-weight Caucasians, the adverse effects of weight gain were more pronounced in those of Japanese and Native Hawaiian descent. Weight change between Qx1 and Qx2 conferred a smaller risk. Conclusion: These findings support the current public-health recommendations for weight control and particularly among ethnic groups at high risk for diabetes.

AB - Aim: To improve our understanding of excess body weight and risk for diabetes type 2, the study examined the influence of weight change in the Hawaii component, including 78,006 Caucasians, Japanese Americans and Native Hawaiians, of the Multiethnic Cohort Study. Methods: Participants aged 58.5 ± 9.2 years completed a questionnaire at cohort entry (Qx1), including weight at age 21, and a follow-up questionnaire 5. years later (Qx2). After 14 years of follow-up, 8892 incident diabetes cases were identified through self-reports or linkups with the major health plans in Hawaii. Cox regression analysis was applied, stratified by age and adjusted for confounders, to estimate hazard ratios (HRs). Results: The mean weight gain from age 21 to Qx1 was 10.5 ± 11.0. kg and, between Qx1 and Qx2, 0.8 ± 5.6. kg. Diabetes risk showed a significant dose-response relationship with weight gain from age 21 (P<0.0001). The respective HRs for a weight gain of 5-10. kg and greater or equal to 25. kg were 1.8 (95% CI: 1.7-2.0) and 7.7 (95% CI: 7.1-8.4), while weight loss of greater than 5. kg significantly reduced diabetes risk (HR = 0.7; 95% CI: 0.6-0.9). The interaction term of weight change since age 21 with ethnicity was also highly significant (P<0.0001). Compared with stable-weight Caucasians, the adverse effects of weight gain were more pronounced in those of Japanese and Native Hawaiian descent. Weight change between Qx1 and Qx2 conferred a smaller risk. Conclusion: These findings support the current public-health recommendations for weight control and particularly among ethnic groups at high risk for diabetes.

KW - BMI

KW - Epidemiology

KW - Ethnicity

KW - Hawaï

KW - Incidence

KW - Longitudinal study

KW - Obesity

KW - Prospective studies

KW - Type 2 diabetes

KW - Weight gain

UR - http://www.scopus.com/inward/record.url?scp=79958820853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958820853&partnerID=8YFLogxK

U2 - 10.1016/j.diabet.2010.10.005

DO - 10.1016/j.diabet.2010.10.005

M3 - Article

C2 - 21193341

AN - SCOPUS:79958820853

VL - 37

SP - 230

EP - 236

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 3

ER -