Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule

T. Abo, A. B. Tilden, Charles M. Balch, K. Kumagai, G. M. Troup, M. D. Cooper

Research output: Contribution to journalArticle

Abstract

The mitogenic effects of isotypically diverse antibodies to the T3 molecule were examined in genetically diverse population groups. Whereas the OKT3 antibody (IgG2a) was mitogenic for blood mononuclear cells from all individuals tested, the 38.1 antibody (IgM) was consistently nonmitogenic. In contrast, studies of the mitogenic effects of the Leu-4 antibody (IgG1) revealed striking ethnic differences. More than 80% of Caucasians and Negroes were good Leu-4 responders, whereas most individuals of Asian origin, including Indian, Japanese, and Chinese, were either Leu-4 nonresponders or Leu-4 low responders. However, the majority of American Indians, as well as a significant minority of Chinese, were good responders. Cell separation studies confirmed that monocytes govern the different mitogenic effects of the anti-T3 antibodies. The results reveal interesting ethnik differences in monocyte accessory function probably mediated via the Fc-γ receptor, in the stimulation of T lymphocytes by an IgG1 antibody against the T3 molecule.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalJournal of Experimental Medicine
Volume160
Issue number1
StatePublished - 1984
Externally publishedYes

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Immunoglobulin G
Lymphocytes
Antibodies
Monocytes
Muromonab-CD3
North American Indians
Fc Receptors
Cell Separation
Population Groups
Immunoglobulin M
Anti-Idiotypic Antibodies
Blood Cells
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

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Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule. / Abo, T.; Tilden, A. B.; Balch, Charles M.; Kumagai, K.; Troup, G. M.; Cooper, M. D.

In: Journal of Experimental Medicine, Vol. 160, No. 1, 1984, p. 303-309.

Research output: Contribution to journalArticle

Abo, T. ; Tilden, A. B. ; Balch, Charles M. ; Kumagai, K. ; Troup, G. M. ; Cooper, M. D. / Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule. In: Journal of Experimental Medicine. 1984 ; Vol. 160, No. 1. pp. 303-309.
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AU - Tilden, A. B.

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AU - Troup, G. M.

AU - Cooper, M. D.

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