Ethnic differences in the anatomical location of colorectal adenomatous polyps

G. J A Offerhaus, Francis M Giardiello, K. W F Tersmette, J. W R Mulder, A. C. Tersmette, G. W. Moore, S. R. Hamilton

Research output: Contribution to journalArticle

Abstract

The ratio of right- to left-sided colonic cancer is increasing, but data on the distribution of its usual precursor lesion, the colorectal adenoma, are contradictory. Therefore, we investigated the prevalence of right- and left-sided colorectal adenomatous polyps from January I, 1970, to September 30, 1989, using the study design of 'epidemiologic necrospy' and the autopsy files of The Johns Hopkins Hospital. Compared with the decade of the 1970's, the 1980's showed a slight decrease in the overall prevalence of right-sided adenomas (6.4 per 1,000, 95% confidence limits 4.7-8.8 vs. 5.1 per 1,000, 95% CL 3.6-6.5), but a marked decrease occurred in left-sided adenomas (11.8 per 1,000, 95% CL 9.3-14.3 vs. 6.7 per 1,000, 95% CL 4.8-8.6). As a result, the ratio of right-sided to left-sided adenomas increased from 0.55 in the 1970's to 0.77 in the 1980's. This increased ratio occurred in both sexes, although prevalences were lower in females, and in whites. Unexpectedly, blacks had a ratio of right-sided to left-sided adenomas greater than unity in both the 1970's and 1980's (1.19 vs. 1.79) due to a relatively high prevalence of right-sided adenomas (5.8 per 1,000, 95% CL 3.6-8.0 in 1970's; 5.8 per 1,000, 95% CL 3.3-8.3 in 1980's), but low prevalences of left-sided adenomas (4.9 per 1,000, 95% CL 3.0-6.8 in 1970's; 3.2 per 1,000, 95% CL 1.2-5.2 in 1980's). The overall adenoma prevalence in blacks was lower than in whites. We conclude that the right-sided predominance of colorectal adenomas in blacks suggests ethnic differences in the pathogenesis of colorectal adenomas. This observtion may have important implications for secondary prevention of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)641-644
Number of pages4
JournalInternational Journal of Cancer
Volume49
Issue number5
StatePublished - 1991

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Adenomatous Polyps
Adenoma
Secondary Prevention
Colonic Neoplasms
Epidemiologic Studies
Colorectal Neoplasms
Autopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Offerhaus, G. J. A., Giardiello, F. M., Tersmette, K. W. F., Mulder, J. W. R., Tersmette, A. C., Moore, G. W., & Hamilton, S. R. (1991). Ethnic differences in the anatomical location of colorectal adenomatous polyps. International Journal of Cancer, 49(5), 641-644.

Ethnic differences in the anatomical location of colorectal adenomatous polyps. / Offerhaus, G. J A; Giardiello, Francis M; Tersmette, K. W F; Mulder, J. W R; Tersmette, A. C.; Moore, G. W.; Hamilton, S. R.

In: International Journal of Cancer, Vol. 49, No. 5, 1991, p. 641-644.

Research output: Contribution to journalArticle

Offerhaus, GJA, Giardiello, FM, Tersmette, KWF, Mulder, JWR, Tersmette, AC, Moore, GW & Hamilton, SR 1991, 'Ethnic differences in the anatomical location of colorectal adenomatous polyps', International Journal of Cancer, vol. 49, no. 5, pp. 641-644.
Offerhaus GJA, Giardiello FM, Tersmette KWF, Mulder JWR, Tersmette AC, Moore GW et al. Ethnic differences in the anatomical location of colorectal adenomatous polyps. International Journal of Cancer. 1991;49(5):641-644.
Offerhaus, G. J A ; Giardiello, Francis M ; Tersmette, K. W F ; Mulder, J. W R ; Tersmette, A. C. ; Moore, G. W. ; Hamilton, S. R. / Ethnic differences in the anatomical location of colorectal adenomatous polyps. In: International Journal of Cancer. 1991 ; Vol. 49, No. 5. pp. 641-644.
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abstract = "The ratio of right- to left-sided colonic cancer is increasing, but data on the distribution of its usual precursor lesion, the colorectal adenoma, are contradictory. Therefore, we investigated the prevalence of right- and left-sided colorectal adenomatous polyps from January I, 1970, to September 30, 1989, using the study design of 'epidemiologic necrospy' and the autopsy files of The Johns Hopkins Hospital. Compared with the decade of the 1970's, the 1980's showed a slight decrease in the overall prevalence of right-sided adenomas (6.4 per 1,000, 95{\%} confidence limits 4.7-8.8 vs. 5.1 per 1,000, 95{\%} CL 3.6-6.5), but a marked decrease occurred in left-sided adenomas (11.8 per 1,000, 95{\%} CL 9.3-14.3 vs. 6.7 per 1,000, 95{\%} CL 4.8-8.6). As a result, the ratio of right-sided to left-sided adenomas increased from 0.55 in the 1970's to 0.77 in the 1980's. This increased ratio occurred in both sexes, although prevalences were lower in females, and in whites. Unexpectedly, blacks had a ratio of right-sided to left-sided adenomas greater than unity in both the 1970's and 1980's (1.19 vs. 1.79) due to a relatively high prevalence of right-sided adenomas (5.8 per 1,000, 95{\%} CL 3.6-8.0 in 1970's; 5.8 per 1,000, 95{\%} CL 3.3-8.3 in 1980's), but low prevalences of left-sided adenomas (4.9 per 1,000, 95{\%} CL 3.0-6.8 in 1970's; 3.2 per 1,000, 95{\%} CL 1.2-5.2 in 1980's). The overall adenoma prevalence in blacks was lower than in whites. We conclude that the right-sided predominance of colorectal adenomas in blacks suggests ethnic differences in the pathogenesis of colorectal adenomas. This observtion may have important implications for secondary prevention of colorectal cancer.",
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AU - Giardiello, Francis M

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AU - Moore, G. W.

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N2 - The ratio of right- to left-sided colonic cancer is increasing, but data on the distribution of its usual precursor lesion, the colorectal adenoma, are contradictory. Therefore, we investigated the prevalence of right- and left-sided colorectal adenomatous polyps from January I, 1970, to September 30, 1989, using the study design of 'epidemiologic necrospy' and the autopsy files of The Johns Hopkins Hospital. Compared with the decade of the 1970's, the 1980's showed a slight decrease in the overall prevalence of right-sided adenomas (6.4 per 1,000, 95% confidence limits 4.7-8.8 vs. 5.1 per 1,000, 95% CL 3.6-6.5), but a marked decrease occurred in left-sided adenomas (11.8 per 1,000, 95% CL 9.3-14.3 vs. 6.7 per 1,000, 95% CL 4.8-8.6). As a result, the ratio of right-sided to left-sided adenomas increased from 0.55 in the 1970's to 0.77 in the 1980's. This increased ratio occurred in both sexes, although prevalences were lower in females, and in whites. Unexpectedly, blacks had a ratio of right-sided to left-sided adenomas greater than unity in both the 1970's and 1980's (1.19 vs. 1.79) due to a relatively high prevalence of right-sided adenomas (5.8 per 1,000, 95% CL 3.6-8.0 in 1970's; 5.8 per 1,000, 95% CL 3.3-8.3 in 1980's), but low prevalences of left-sided adenomas (4.9 per 1,000, 95% CL 3.0-6.8 in 1970's; 3.2 per 1,000, 95% CL 1.2-5.2 in 1980's). The overall adenoma prevalence in blacks was lower than in whites. We conclude that the right-sided predominance of colorectal adenomas in blacks suggests ethnic differences in the pathogenesis of colorectal adenomas. This observtion may have important implications for secondary prevention of colorectal cancer.

AB - The ratio of right- to left-sided colonic cancer is increasing, but data on the distribution of its usual precursor lesion, the colorectal adenoma, are contradictory. Therefore, we investigated the prevalence of right- and left-sided colorectal adenomatous polyps from January I, 1970, to September 30, 1989, using the study design of 'epidemiologic necrospy' and the autopsy files of The Johns Hopkins Hospital. Compared with the decade of the 1970's, the 1980's showed a slight decrease in the overall prevalence of right-sided adenomas (6.4 per 1,000, 95% confidence limits 4.7-8.8 vs. 5.1 per 1,000, 95% CL 3.6-6.5), but a marked decrease occurred in left-sided adenomas (11.8 per 1,000, 95% CL 9.3-14.3 vs. 6.7 per 1,000, 95% CL 4.8-8.6). As a result, the ratio of right-sided to left-sided adenomas increased from 0.55 in the 1970's to 0.77 in the 1980's. This increased ratio occurred in both sexes, although prevalences were lower in females, and in whites. Unexpectedly, blacks had a ratio of right-sided to left-sided adenomas greater than unity in both the 1970's and 1980's (1.19 vs. 1.79) due to a relatively high prevalence of right-sided adenomas (5.8 per 1,000, 95% CL 3.6-8.0 in 1970's; 5.8 per 1,000, 95% CL 3.3-8.3 in 1980's), but low prevalences of left-sided adenomas (4.9 per 1,000, 95% CL 3.0-6.8 in 1970's; 3.2 per 1,000, 95% CL 1.2-5.2 in 1980's). The overall adenoma prevalence in blacks was lower than in whites. We conclude that the right-sided predominance of colorectal adenomas in blacks suggests ethnic differences in the pathogenesis of colorectal adenomas. This observtion may have important implications for secondary prevention of colorectal cancer.

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