Ethnic Differences in Diffuse Noxious Inhibitory Controls

Claudia Campbell, Christopher R. France, Michael E. Robinson, Henrietta L. Logan, Gary R. Geffken, Roger B. Fillingim

Research output: Contribution to journalArticle

Abstract

Substantial evidence indicates that the experience of both clinical and experimental pain differs among ethnic groups. Specifically, African Americans generally report higher levels of clinical pain and greater sensitivity to experimentally induced pain; however, little research has examined the origins of these differences. Differences in central pain-inhibitory mechanisms may contribute to this disparity. Diffuse noxious inhibitory controls (DNIC), or counterirritation, is a phenomenon thought to reflect descending inhibition of pain signals. The current study assessed DNIC in 57 healthy young adults from 2 different ethnic groups: African Americans and non-Hispanic whites. Repeated assessments of the nociceptive flexion reflex (NFR) as well as ratings of electrical pain were obtained before, during, and after an ischemic arm pain procedure (as well as a sham procedure). The DNIC condition (ie, ischemic arm pain) produced substantial reductions in pain ratings as well as electrophysiologic measures of the NFR for all participants when compared with the sham condition (P <.001). The DNIC condition produced significantly greater reductions in verbal pain ratings among non-Hispanic whites when compared with African Americans (P = .02), whereas ethnic groups showed comparable reductions in NFR. The findings of this study suggest differences in endogenous pain inhibition between African Americans and non-Hispanic whites and that additional research to determine the mechanisms underlying these effects is warranted. Perspective: This study adds to the growing literature examining ethnic differences in experimental pain perception. Our data suggest that these variations may be influenced by differences in descending inhibition.

Original languageEnglish (US)
Pages (from-to)759-766
Number of pages8
JournalJournal of Pain
Volume9
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Diffuse Noxious Inhibitory Control
Pain
African Americans
Ethnic Groups
Reflex
Pain Perception
Research

Keywords

  • diffuse noxious inhibitory controls
  • ethnic differences
  • Experimental pain
  • nociceptive flexion reflex

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Campbell, C., France, C. R., Robinson, M. E., Logan, H. L., Geffken, G. R., & Fillingim, R. B. (2008). Ethnic Differences in Diffuse Noxious Inhibitory Controls. Journal of Pain, 9(8), 759-766. https://doi.org/10.1016/j.jpain.2008.03.010

Ethnic Differences in Diffuse Noxious Inhibitory Controls. / Campbell, Claudia; France, Christopher R.; Robinson, Michael E.; Logan, Henrietta L.; Geffken, Gary R.; Fillingim, Roger B.

In: Journal of Pain, Vol. 9, No. 8, 08.2008, p. 759-766.

Research output: Contribution to journalArticle

Campbell, C, France, CR, Robinson, ME, Logan, HL, Geffken, GR & Fillingim, RB 2008, 'Ethnic Differences in Diffuse Noxious Inhibitory Controls', Journal of Pain, vol. 9, no. 8, pp. 759-766. https://doi.org/10.1016/j.jpain.2008.03.010
Campbell C, France CR, Robinson ME, Logan HL, Geffken GR, Fillingim RB. Ethnic Differences in Diffuse Noxious Inhibitory Controls. Journal of Pain. 2008 Aug;9(8):759-766. https://doi.org/10.1016/j.jpain.2008.03.010
Campbell, Claudia ; France, Christopher R. ; Robinson, Michael E. ; Logan, Henrietta L. ; Geffken, Gary R. ; Fillingim, Roger B. / Ethnic Differences in Diffuse Noxious Inhibitory Controls. In: Journal of Pain. 2008 ; Vol. 9, No. 8. pp. 759-766.
@article{0f5e993d97bc465685a68aaccb17bff2,
title = "Ethnic Differences in Diffuse Noxious Inhibitory Controls",
abstract = "Substantial evidence indicates that the experience of both clinical and experimental pain differs among ethnic groups. Specifically, African Americans generally report higher levels of clinical pain and greater sensitivity to experimentally induced pain; however, little research has examined the origins of these differences. Differences in central pain-inhibitory mechanisms may contribute to this disparity. Diffuse noxious inhibitory controls (DNIC), or counterirritation, is a phenomenon thought to reflect descending inhibition of pain signals. The current study assessed DNIC in 57 healthy young adults from 2 different ethnic groups: African Americans and non-Hispanic whites. Repeated assessments of the nociceptive flexion reflex (NFR) as well as ratings of electrical pain were obtained before, during, and after an ischemic arm pain procedure (as well as a sham procedure). The DNIC condition (ie, ischemic arm pain) produced substantial reductions in pain ratings as well as electrophysiologic measures of the NFR for all participants when compared with the sham condition (P <.001). The DNIC condition produced significantly greater reductions in verbal pain ratings among non-Hispanic whites when compared with African Americans (P = .02), whereas ethnic groups showed comparable reductions in NFR. The findings of this study suggest differences in endogenous pain inhibition between African Americans and non-Hispanic whites and that additional research to determine the mechanisms underlying these effects is warranted. Perspective: This study adds to the growing literature examining ethnic differences in experimental pain perception. Our data suggest that these variations may be influenced by differences in descending inhibition.",
keywords = "diffuse noxious inhibitory controls, ethnic differences, Experimental pain, nociceptive flexion reflex",
author = "Claudia Campbell and France, {Christopher R.} and Robinson, {Michael E.} and Logan, {Henrietta L.} and Geffken, {Gary R.} and Fillingim, {Roger B.}",
year = "2008",
month = "8",
doi = "10.1016/j.jpain.2008.03.010",
language = "English (US)",
volume = "9",
pages = "759--766",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "Churchill Livingstone",
number = "8",

}

TY - JOUR

T1 - Ethnic Differences in Diffuse Noxious Inhibitory Controls

AU - Campbell, Claudia

AU - France, Christopher R.

AU - Robinson, Michael E.

AU - Logan, Henrietta L.

AU - Geffken, Gary R.

AU - Fillingim, Roger B.

PY - 2008/8

Y1 - 2008/8

N2 - Substantial evidence indicates that the experience of both clinical and experimental pain differs among ethnic groups. Specifically, African Americans generally report higher levels of clinical pain and greater sensitivity to experimentally induced pain; however, little research has examined the origins of these differences. Differences in central pain-inhibitory mechanisms may contribute to this disparity. Diffuse noxious inhibitory controls (DNIC), or counterirritation, is a phenomenon thought to reflect descending inhibition of pain signals. The current study assessed DNIC in 57 healthy young adults from 2 different ethnic groups: African Americans and non-Hispanic whites. Repeated assessments of the nociceptive flexion reflex (NFR) as well as ratings of electrical pain were obtained before, during, and after an ischemic arm pain procedure (as well as a sham procedure). The DNIC condition (ie, ischemic arm pain) produced substantial reductions in pain ratings as well as electrophysiologic measures of the NFR for all participants when compared with the sham condition (P <.001). The DNIC condition produced significantly greater reductions in verbal pain ratings among non-Hispanic whites when compared with African Americans (P = .02), whereas ethnic groups showed comparable reductions in NFR. The findings of this study suggest differences in endogenous pain inhibition between African Americans and non-Hispanic whites and that additional research to determine the mechanisms underlying these effects is warranted. Perspective: This study adds to the growing literature examining ethnic differences in experimental pain perception. Our data suggest that these variations may be influenced by differences in descending inhibition.

AB - Substantial evidence indicates that the experience of both clinical and experimental pain differs among ethnic groups. Specifically, African Americans generally report higher levels of clinical pain and greater sensitivity to experimentally induced pain; however, little research has examined the origins of these differences. Differences in central pain-inhibitory mechanisms may contribute to this disparity. Diffuse noxious inhibitory controls (DNIC), or counterirritation, is a phenomenon thought to reflect descending inhibition of pain signals. The current study assessed DNIC in 57 healthy young adults from 2 different ethnic groups: African Americans and non-Hispanic whites. Repeated assessments of the nociceptive flexion reflex (NFR) as well as ratings of electrical pain were obtained before, during, and after an ischemic arm pain procedure (as well as a sham procedure). The DNIC condition (ie, ischemic arm pain) produced substantial reductions in pain ratings as well as electrophysiologic measures of the NFR for all participants when compared with the sham condition (P <.001). The DNIC condition produced significantly greater reductions in verbal pain ratings among non-Hispanic whites when compared with African Americans (P = .02), whereas ethnic groups showed comparable reductions in NFR. The findings of this study suggest differences in endogenous pain inhibition between African Americans and non-Hispanic whites and that additional research to determine the mechanisms underlying these effects is warranted. Perspective: This study adds to the growing literature examining ethnic differences in experimental pain perception. Our data suggest that these variations may be influenced by differences in descending inhibition.

KW - diffuse noxious inhibitory controls

KW - ethnic differences

KW - Experimental pain

KW - nociceptive flexion reflex

UR - http://www.scopus.com/inward/record.url?scp=47549099963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47549099963&partnerID=8YFLogxK

U2 - 10.1016/j.jpain.2008.03.010

DO - 10.1016/j.jpain.2008.03.010

M3 - Article

C2 - 18482870

AN - SCOPUS:47549099963

VL - 9

SP - 759

EP - 766

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 8

ER -