Ethical Issues in Research to Improve the Management of Malignant Bowel Obstruction: Challenges and Recommendations

Alice Laneader, Peter Angelos, Betty Ferrell, Ann Kolker, Thomas Miner, Geraldine Padilla, Julie Swaney, Robert S. Krouse, David Casarett

Research output: Contribution to journalArticle

Abstract

Research to improve the care of patients with malignant bowel obstruction (MBO) is urgently needed. In particular, there is an urgent need for high-quality descriptive research, including prospective cohort studies, as well as randomized controlled trials to define optimal management strategies. However, investigators and clinicians face numerous barriers in conducting high-quality research in this patient population. These barriers include lack of funding, difficulties in identifying eligible patients, and a variety of practical and methodological challenges of designing these studies. In addition, there are a variety of ethical challenges that arise in the design and conduct of studies of MBO and particularly in the conduct of clinical trials. In this article, we address four categories of ethical issues: study design, recruitment, informed consent, and Institutional Review Board review. For each, we outline salient issues and suggest recommendations for enhancing the ethics of MBO studies, including interventional trials.

Original languageEnglish (US)
JournalJournal of Pain and Symptom Management
Volume34
Issue number1 SUPPL.
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

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Ethics
Research
Research Ethics Committees
Informed Consent
Patient Care
Cohort Studies
Randomized Controlled Trials
Research Personnel
Clinical Trials
Prospective Studies
Population

Keywords

  • End of life
  • ethics
  • palliative care
  • research ethics

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Ethical Issues in Research to Improve the Management of Malignant Bowel Obstruction : Challenges and Recommendations. / Laneader, Alice; Angelos, Peter; Ferrell, Betty; Kolker, Ann; Miner, Thomas; Padilla, Geraldine; Swaney, Julie; Krouse, Robert S.; Casarett, David.

In: Journal of Pain and Symptom Management, Vol. 34, No. 1 SUPPL., 01.07.2007.

Research output: Contribution to journalArticle

Laneader, A, Angelos, P, Ferrell, B, Kolker, A, Miner, T, Padilla, G, Swaney, J, Krouse, RS & Casarett, D 2007, 'Ethical Issues in Research to Improve the Management of Malignant Bowel Obstruction: Challenges and Recommendations', Journal of Pain and Symptom Management, vol. 34, no. 1 SUPPL.. https://doi.org/10.1016/j.jpainsymman.2007.04.007
Laneader, Alice ; Angelos, Peter ; Ferrell, Betty ; Kolker, Ann ; Miner, Thomas ; Padilla, Geraldine ; Swaney, Julie ; Krouse, Robert S. ; Casarett, David. / Ethical Issues in Research to Improve the Management of Malignant Bowel Obstruction : Challenges and Recommendations. In: Journal of Pain and Symptom Management. 2007 ; Vol. 34, No. 1 SUPPL.
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