Ethanol-induced coronary vasodilation in patients with and without coronary artery disease

Ricardo G. Cigarroa, Richard A. Lange, Jeffrey J. Popma, Gary Yurow, Michael N. Sills, Brian G. Firth, L. David Hillis

Research output: Contribution to journalArticle

Abstract

To assess the influence of ethanol on coronary arterial blood flow and dimensions, we measured coronary sinus blood flow in 35 subjects (23 men and 12 women, aged 38 to 69 years; (29 with and 6 without coronary artery disease) before and during a 15- to 30-minute intracoronary infusion of (1) 5% dextrose in water (n=15, controls) or (2) 5% ethanol in 5% dextrose in water (n=20). In the controls heart rate, arterial pressure, and coronary sinus blood flow were unchanged. In those receiving ethanol at a rate that produced a concentration in coronary sinus blood of 285±102 (mean±SD) mg/dl, heart rate-systolic arterial pressure product was unchanged; coronary sinus blood flow rose 27±36%, and coronary vascular resistance fell 17±22% (p

Original languageEnglish (US)
Pages (from-to)254-259
Number of pages6
JournalAmerican Heart Journal
Volume119
Issue number2 PART 1
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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