Ethanol-induced coronary vasodilation in patients with and without coronary artery disease

Ricardo G. Cigarroa; Richard A. Lange; Jeffrey J. Popma; Gary Yurow; Michael N. Sills; Brian G. Firth; L. David Hillis

doi:10.1016/S0002-8703(05)80013-4

Ethanol-induced coronary vasodilation in patients with and without coronary artery disease

Ricardo G. Cigarroa, Richard A. Lange, Jeffrey J. Popma, Gary Yurow, Michael N. Sills, Brian G. Firth, L. David Hillis

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

To assess the influence of ethanol on coronary arterial blood flow and dimensions, we measured coronary sinus blood flow in 35 subjects (23 men and 12 women, aged 38 to 69 years; (29 with and 6 without coronary artery disease) before and during a 15- to 30-minute intracoronary infusion of (1) 5% dextrose in water (n=15, controls) or (2) 5% ethanol in 5% dextrose in water (n=20). In the controls heart rate, arterial pressure, and coronary sinus blood flow were unchanged. In those receiving ethanol at a rate that produced a concentration in coronary sinus blood of 285±102 (mean±SD) mg/dl, heart rate-systolic arterial pressure product was unchanged; coronary sinus blood flow rose 27±36%, and coronary vascular resistance fell 17±22% (p

Original language	English (US)
Pages (from-to)	254-259
Number of pages	6
Journal	American Heart Journal
Volume	119
Issue number	2 PART 1
DOIs	https://doi.org/10.1016/S0002-8703(05)80013-4
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-8703(05)80013-4

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title = "Ethanol-induced coronary vasodilation in patients with and without coronary artery disease",

abstract = "To assess the influence of ethanol on coronary arterial blood flow and dimensions, we measured coronary sinus blood flow in 35 subjects (23 men and 12 women, aged 38 to 69 years; (29 with and 6 without coronary artery disease) before and during a 15- to 30-minute intracoronary infusion of (1) 5% dextrose in water (n=15, controls) or (2) 5% ethanol in 5% dextrose in water (n=20). In the controls heart rate, arterial pressure, and coronary sinus blood flow were unchanged. In those receiving ethanol at a rate that produced a concentration in coronary sinus blood of 285±102 (mean±SD) mg/dl, heart rate-systolic arterial pressure product was unchanged; coronary sinus blood flow rose 27±36%, and coronary vascular resistance fell 17±22% (p",

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AU - Cigarroa, Ricardo G.

AU - Lange, Richard A.

AU - Popma, Jeffrey J.

AU - Yurow, Gary

AU - Sills, Michael N.

AU - Firth, Brian G.

AU - Hillis, L. David

PY - 1990

Y1 - 1990

N2 - To assess the influence of ethanol on coronary arterial blood flow and dimensions, we measured coronary sinus blood flow in 35 subjects (23 men and 12 women, aged 38 to 69 years; (29 with and 6 without coronary artery disease) before and during a 15- to 30-minute intracoronary infusion of (1) 5% dextrose in water (n=15, controls) or (2) 5% ethanol in 5% dextrose in water (n=20). In the controls heart rate, arterial pressure, and coronary sinus blood flow were unchanged. In those receiving ethanol at a rate that produced a concentration in coronary sinus blood of 285±102 (mean±SD) mg/dl, heart rate-systolic arterial pressure product was unchanged; coronary sinus blood flow rose 27±36%, and coronary vascular resistance fell 17±22% (p

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Ethanol-induced coronary vasodilation in patients with and without coronary artery disease

Abstract

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