Ethanol increases opioid activity in plasma of normal volunteers

D. Naber, M. G. Soble, D. Pickar

Research output: Contribution to journalArticle

Abstract

The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

Original languageEnglish (US)
Pages (from-to)160-161
Number of pages2
JournalPharmacopsychiatria
Volume14
Issue number5
StatePublished - 1981
Externally publishedYes

Fingerprint

Opioid Analgesics
Endorphins
Healthy Volunteers
Ethanol
Opiate Alkaloids
Radioligand Assay
Coma
Naloxone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Naber, D., Soble, M. G., & Pickar, D. (1981). Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatria, 14(5), 160-161.

Ethanol increases opioid activity in plasma of normal volunteers. / Naber, D.; Soble, M. G.; Pickar, D.

In: Pharmacopsychiatria, Vol. 14, No. 5, 1981, p. 160-161.

Research output: Contribution to journalArticle

Naber, D, Soble, MG & Pickar, D 1981, 'Ethanol increases opioid activity in plasma of normal volunteers', Pharmacopsychiatria, vol. 14, no. 5, pp. 160-161.
Naber, D. ; Soble, M. G. ; Pickar, D. / Ethanol increases opioid activity in plasma of normal volunteers. In: Pharmacopsychiatria. 1981 ; Vol. 14, No. 5. pp. 160-161.
@article{c058f72dfee247a4b1671f0896f50b9a,
title = "Ethanol increases opioid activity in plasma of normal volunteers",
abstract = "The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400{\%}; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.",
author = "D. Naber and Soble, {M. G.} and D. Pickar",
year = "1981",
language = "English (US)",
volume = "14",
pages = "160--161",
journal = "Pharmacopsychiatry",
issn = "0176-3679",
publisher = "Georg Thieme Verlag",
number = "5",

}

TY - JOUR

T1 - Ethanol increases opioid activity in plasma of normal volunteers

AU - Naber, D.

AU - Soble, M. G.

AU - Pickar, D.

PY - 1981

Y1 - 1981

N2 - The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

AB - The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

UR - http://www.scopus.com/inward/record.url?scp=0019824936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019824936&partnerID=8YFLogxK

M3 - Article

C2 - 6270709

AN - SCOPUS:0019824936

VL - 14

SP - 160

EP - 161

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

SN - 0176-3679

IS - 5

ER -