Ethanol increases opioid activity in plasma of normal volunteers

D. Naber; M. G. Soble; D. Pickar

Ethanol increases opioid activity in plasma of normal volunteers

D. Naber, M. G. Soble, D. Pickar

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

Original language	English (US)
Pages (from-to)	160-161
Number of pages	2
Journal	Pharmacopsychiatria
Volume	14
Issue number	5
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Ethanol increases opioid activity in plasma of normal volunteers",

abstract = "The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.",

author = "D. Naber and Soble, {M. G.} and D. Pickar",

year = "1981",

language = "English (US)",

volume = "14",

pages = "160--161",

journal = "Pharmacopsychiatria",

issn = "0720-4280",

publisher = "Georg Thieme Verlag",

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T1 - Ethanol increases opioid activity in plasma of normal volunteers

AU - Naber, D.

AU - Soble, M. G.

AU - Pickar, D.

PY - 1981

Y1 - 1981

N2 - The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

AB - The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

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M3 - Article

C2 - 6270709

AN - SCOPUS:0019824936

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Ethanol increases opioid activity in plasma of normal volunteers

Abstract

ASJC Scopus subject areas

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