Ethanol increases opioid activity in plasma of normal volunteers

D. Naber, M. G. Soble, D. Pickar

Research output: Contribution to journalArticle


The effect of acute ethanol administration on plasma levels of β-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptor assay, increased significantly with peak rises of more than 400%; levels of β-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.

Original languageEnglish (US)
Pages (from-to)160-161
Number of pages2
Issue number5
Publication statusPublished - 1981
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Naber, D., Soble, M. G., & Pickar, D. (1981). Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatria, 14(5), 160-161.