Ethanol affects the function of gamma-aminobutyric acid transporter I in mice brain

Jie Jiang, Jia Hua Hu, Min Wu, L. H. Guo, Jian Fei

Research output: Contribution to journalArticle

Abstract

It has been suggested that GABAergic system was involved in ethanol tolerance and addiction. Our previous work indicated both acute and chronic ethanol treatment enhanced the activity of GABA transporters in mouse brain. However, the expression level of GAT1 in CNS does not change, neither does the affinity of GABA transporters. In the present study, we demonstrated that GAT1 distribution on presynaptic membrane was altered after acute and chronic ethanol administration. Furthermore, the phosphorylation levels of GAT1 on three sites including Ser, Tyr and Thr were decreased. These data suggested that ethanol enhanced the function of GATs by means of inducing GAT1 redistribution in the cell and dephosphorylation may play a role in this process.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalShi yan sheng wu xue bao
Volume37
Issue number4
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Medicine(all)

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    Jiang, J., Hu, J. H., Wu, M., Guo, L. H., & Fei, J. (2004). Ethanol affects the function of gamma-aminobutyric acid transporter I in mice brain. Shi yan sheng wu xue bao, 37(4), 315-320.