Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum

Robert E. Hruska, Ellen K. Silbergeld

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


Estrogen (125 μg/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptors stimulation.

Original languageEnglish (US)
Pages (from-to)397-400
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number4
StatePublished - Feb 22 1980
Externally publishedYes


  • Dopamine receptors
  • Estrogen
  • Stereotypy

ASJC Scopus subject areas

  • Pharmacology


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