Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum

Robert E. Hruska; Ellen K. Silbergeld

doi:10.1016/0014-2999(80)90081-3

Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum

Robert E. Hruska, Ellen K. Silbergeld

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Estrogen (125 μg/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [³H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptors stimulation.

Original language	English (US)
Pages (from-to)	397-400
Number of pages	4
Journal	European Journal of Pharmacology
Volume	61
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(80)90081-3
State	Published - Feb 22 1980
Externally published	Yes

Keywords

Dopamine receptors
Estrogen
Stereotypy

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(80)90081-3

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title = "Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum",

abstract = "Estrogen (125 μg/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptors stimulation.",

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AU - Silbergeld, Ellen K.

PY - 1980/2/22

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AB - Estrogen (125 μg/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptors stimulation.

KW - Dopamine receptors

KW - Estrogen

KW - Stereotypy

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IS - 4

ER -

Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum

Abstract

Keywords

ASJC Scopus subject areas

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