Estrogen replacement therapy and MRI-demonstrated cerebral infarcts, white matter changes, and brain atrophy in older women

The Cardiovascular Health Study

R. Luoto, T. Manolio, E. Meilahn, R. Bhadelia, C. Furberg, L. Cooper, Michael A Kraut

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: We studied the relationship between the use of estrogen replacement therapy (ERT) and cerebral magnetic resonance imaging (MRI) abnormalities among older women. DESIGN: A population-based prospective study (Cardiovascular Health Study). SETTING: Four regions in the United States. PARTICIPANTS: A total of 2133 (62.9% of the eligible) women aged 65 to 95 years (mean age 74.8), on whom MRI was performed in 1992-1994. MEASUREMENTS: Presence of global brain atrophy, white matter changes, small infarct-like lesion (ILL) (

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalJournal of the American Geriatrics Society
Volume48
Issue number5
StatePublished - May 2000

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Estrogen Replacement Therapy
Atrophy
Magnetic Resonance Imaging
Health
Brain
Prospective Studies
Population
White Matter

Keywords

  • Estrogen
  • Hormone replacement therapy
  • Magnetic resonance imaging
  • MMSE
  • Population study

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Estrogen replacement therapy and MRI-demonstrated cerebral infarcts, white matter changes, and brain atrophy in older women : The Cardiovascular Health Study. / Luoto, R.; Manolio, T.; Meilahn, E.; Bhadelia, R.; Furberg, C.; Cooper, L.; Kraut, Michael A.

In: Journal of the American Geriatrics Society, Vol. 48, No. 5, 05.2000, p. 467-472.

Research output: Contribution to journalArticle

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