Estrogen regulation of protein expression and signaling pathways in the heart

Elizabeth Murphy, Charles Jr Steenbergen

Research output: Contribution to journalArticle

Abstract

Sex differences in cardiovascular disease and cardiac physiology have been reported in humans as well as in animal models. Premenopausal women have reduced cardiovascular disease compared to men, but the incidence of cardiovascular disease in women increases following menopause. Sex differences in cardiomyocytes likely contribute to the differences in male-female physiology and response to disease. Sex differences in the heart have been noted in electrophysiology, contractility, signaling, metabolism, and cardioprotection. These differences appear to be due, at least in part, to differences in gene and protein expression as well as in posttranslational protein modifications. This review will focus primarily on estrogen-mediated male-female differences in protein expression and signaling pathways in the heart and cardiac cells. It should be emphasized that these basic differences are not intrinsically beneficial or detrimental per se; the difference can be good or bad depending on the context and circumstances.

Original languageEnglish (US)
Article number6
JournalBiology of Sex Differences
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2014

Fingerprint

Sex Characteristics
Estrogens
Cardiovascular Diseases
Disease
regulation
physiology
Proteins
Electrophysiology
Post Translational Protein Processing
Menopause
Cardiac Myocytes
menopause
Animal Models
Gene Expression
incidence
animal
Incidence

Keywords

  • Cardiac
  • Estrogen
  • Ischemia-reperfusion
  • Metabolism

ASJC Scopus subject areas

  • Endocrinology
  • Gender Studies

Cite this

Estrogen regulation of protein expression and signaling pathways in the heart. / Murphy, Elizabeth; Steenbergen, Charles Jr.

In: Biology of Sex Differences, Vol. 5, No. 1, 6, 01.03.2014.

Research output: Contribution to journalArticle

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