Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen

N. I. Ntukidem, A. T. Nguyen, Vered Stearns, M. Rehman, A. Schott, T. Skaar, Y. Jin, P. Blanche, L. Li, S. Lemler, J. Hayden, R. M. Krauss, Z. Desta, D. A. Flockhart, D. F. Hayes

Research output: Contribution to journalArticle

Abstract

Tamoxifen induces important changes in serum lipid profiles in some women; however, little information is available to predict which women will experience improved lipid profiles during tamoxifen therapy. As part of a multicenter prospective observational trial in 176 breast cancer patients, we tested the hypothesis that tamoxifen-induced lipid changes were associated with genetic variants in candidate target genes (CYP2D6, ESR1, and ESR2). Tamoxifen lowered low-density lipoprotein cholesterol (P

Original languageEnglish (US)
Pages (from-to)702-710
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume83
Issue number5
DOIs
Publication statusPublished - May 30 2008

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ASJC Scopus subject areas

  • Pharmacology

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