Estrogen metabolism in the (New Zealand black × New Zealand white)F1 Murine model of systemic lupus erythematosus

Alan N. Baer, Floyd A. Green

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatic microsomal estrogen metabolism was analyzed in the (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1) murine model of systemic lupus erythematosus. Both the estrogen 2‐hydroxylase activity (per mg microsomal protein) and the hepatic cytochrome P‐450 content were higher in premorbid (NZB × NZW)F1 mice, as compared with similarly aged nonautoimmune mice. However, these differences were not associated with alterations in the relative formation of the 2‐hydroxylated and the 16α‐hydroxylated metabolites. The development of overt nephritis was associated with a decrease in estrogen metabolic activity, but not with any alteration in the distribution of estrogen metabolites. Thus, estrogen metabolism was not altered in premorbid (NZB × NZW)F1 mice in a manner that would result in abnormal retention of hormonally active metabolites.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalArthritis & Rheumatism
Volume33
Issue number1
DOIs
StatePublished - Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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