Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels

Hong Lou, Yejun Zhao, Patrick Delafontaine, Teruaki Kodama, Nevin Katz, Peter W. Ramwell, Marie L. Foegh

Research output: Contribution to journalArticle

Abstract

Background: Estrogen protects against cardiovascular disease in both patients and animal models and regulates insulin-like growth factor-I (IGF- I), an important cell-cycle progression factor. Methods and Results: Smooth muscle cells and tissues were harvested from male recipient rabbits that 6 weeks earlier had received a cardiac allograft transplant consisting of a donor heart and ascending aorta. Segments of the ascending aorta from the native and allograft hearts from 9 placebo-treated and 8 estradiol-treated recipients were compared by using IGF-I-stimulated [3H]thymidine incorporation. The responses of the native vessel segments were similar (175.3±32% and 166.9±41%, respectively; P>.05) whether or not the recipients had been treated for 6 weeks with estradiol. In the grafts, however, estradiol markedly inhibited vascular cell thymidine incorporation (328.04±56% compared with 67.3±11%; P

Original languageEnglish (US)
Pages (from-to)927-933
Number of pages7
JournalCirculation
Volume96
Issue number3
StatePublished - Aug 5 1997
Externally publishedYes

Keywords

  • Coronary disease
  • Hormones
  • Immunohistochemistry
  • Muscle, smooth
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels'. Together they form a unique fingerprint.

  • Cite this

    Lou, H., Zhao, Y., Delafontaine, P., Kodama, T., Katz, N., Ramwell, P. W., & Foegh, M. L. (1997). Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels. Circulation, 96(3), 927-933.