TY - JOUR
T1 - Estrogen action and cytoplasmic signaling pathways. Part II
T2 - The role of growth factors and phosphorylation in estrogen signaling
AU - Driggers, Paul H.
AU - Segars, James H.
N1 - Funding Information:
We thank George Anderson for help in preparation of the article and Domenica Rubino and John Wu for critical reading. P.H.D. is supported in part by a grant from the DoD.
PY - 2002/12
Y1 - 2002/12
N2 - In recent years, distinct signaling pathways involving specific complexes of cytoplasmic proteins have been shown to orchestrate estrogen action. These pathways might supplement or augment genomic effects of estrogen that are attributable to transcriptional activation by liganded receptor. Signals might be transduced through phosphorylation of the estrogen receptors (ERs), or indirectly through effects upon transcriptional coactivators or cell receptors. Estrogen signaling is coupled to growth factor signaling with feedback mechanisms directly impacting function of growth factor receptors. These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs.
AB - In recent years, distinct signaling pathways involving specific complexes of cytoplasmic proteins have been shown to orchestrate estrogen action. These pathways might supplement or augment genomic effects of estrogen that are attributable to transcriptional activation by liganded receptor. Signals might be transduced through phosphorylation of the estrogen receptors (ERs), or indirectly through effects upon transcriptional coactivators or cell receptors. Estrogen signaling is coupled to growth factor signaling with feedback mechanisms directly impacting function of growth factor receptors. These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs.
UR - http://www.scopus.com/inward/record.url?scp=0038407651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038407651&partnerID=8YFLogxK
U2 - 10.1016/S1043-2760(02)00634-3
DO - 10.1016/S1043-2760(02)00634-3
M3 - Review article
C2 - 12431838
AN - SCOPUS:0038407651
VL - 13
SP - 422
EP - 427
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 10
ER -