Abstract
In recent years, distinct signaling pathways involving specific complexes of cytoplasmic proteins have been shown to orchestrate estrogen action. These pathways might supplement or augment genomic effects of estrogen that are attributable to transcriptional activation by liganded receptor. Signals might be transduced through phosphorylation of the estrogen receptors (ERs), or indirectly through effects upon transcriptional coactivators or cell receptors. Estrogen signaling is coupled to growth factor signaling with feedback mechanisms directly impacting function of growth factor receptors. These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 422-428 |
| Number of pages | 7 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 13 |
| Issue number | 10 |
| DOIs | |
| State | Published - Dec 2002 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Estrogen action and cytoplasmic signaling pathways. Part II : The role of growth factors and phosphorylation in estrogen signaling. / Driggers, Paul H.; Segars, James.
In: Trends in Endocrinology and Metabolism, Vol. 13, No. 10, 12.2002, p. 422-428.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estrogen action and cytoplasmic signaling pathways. Part II
T2 - The role of growth factors and phosphorylation in estrogen signaling
AU - Driggers, Paul H.
AU - Segars, James
PY - 2002/12
Y1 - 2002/12
N2 - In recent years, distinct signaling pathways involving specific complexes of cytoplasmic proteins have been shown to orchestrate estrogen action. These pathways might supplement or augment genomic effects of estrogen that are attributable to transcriptional activation by liganded receptor. Signals might be transduced through phosphorylation of the estrogen receptors (ERs), or indirectly through effects upon transcriptional coactivators or cell receptors. Estrogen signaling is coupled to growth factor signaling with feedback mechanisms directly impacting function of growth factor receptors. These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs.
AB - In recent years, distinct signaling pathways involving specific complexes of cytoplasmic proteins have been shown to orchestrate estrogen action. These pathways might supplement or augment genomic effects of estrogen that are attributable to transcriptional activation by liganded receptor. Signals might be transduced through phosphorylation of the estrogen receptors (ERs), or indirectly through effects upon transcriptional coactivators or cell receptors. Estrogen signaling is coupled to growth factor signaling with feedback mechanisms directly impacting function of growth factor receptors. These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs.
UR - http://www.scopus.com/inward/record.url?scp=0038407651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038407651&partnerID=8YFLogxK
U2 - 10.1016/S1043-2760(02)00634-3
DO - 10.1016/S1043-2760(02)00634-3
M3 - Article
C2 - 12431838
AN - SCOPUS:0038407651
VL - 13
SP - 422
EP - 428
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 10
ER -