Estradiol-induced changes in rabbit luteal cell progestin production and cholesterol and cholesterol ester content

John A. Holt, James R. Schreiber, Barry R. Zirkin

Research output: Contribution to journalArticle

Abstract

Estradiol deprivation in vivo causes accumulation of cholesterol and cholesterol ester in the corpora lutea of pseudo-pregnant rabbits within 24 hours. These accumulations occur concomitantly with an abrupt cessation of progestin production. Retreatment with estradiol restores progestin production and can block further increases in cholesterol accumulation (per mg total tissue protein). Ample quantities of precursor cholesterol ester and cholesterol substrate are present in corpora lutea when progestin falls because of estradiol deprivation. We conclude therefore that the gonadotropic action of estradiol is, in part, because of its stimulation of cholesterol conversion to progestins.

Original languageEnglish (US)
Pages (from-to)1026-1033
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume113
Issue number3
DOIs
StatePublished - Jun 29 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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