Estradiol augments peri-infarct cerebral vascular density in experimental stroke

Agnieszka A. Ardelt; Naseem Anjum; Kiran F. Rajneesh; Piotr Kulesza; Raymond C. Koehler

doi:10.1016/j.expneurol.2007.04.002

Estradiol augments peri-infarct cerebral vascular density in experimental stroke

Agnieszka A. Ardelt, Naseem Anjum, Kiran F. Rajneesh, Piotr Kulesza, Raymond C. Koehler

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.

Original language	English (US)
Pages (from-to)	95-100
Number of pages	6
Journal	Experimental Neurology
Volume	206
Issue number	1
DOIs	https://doi.org/10.1016/j.expneurol.2007.04.002
State	Published - Jul 2007

Keywords

Angiogenesis
Estradiol
Infarct
Penumbra
Rat
Stroke

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2007.04.002

Cite this

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abstract = "Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.",

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AU - Kulesza, Piotr

AU - Koehler, Raymond C.

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Estradiol augments peri-infarct cerebral vascular density in experimental stroke

Abstract

Keywords

ASJC Scopus subject areas

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