Estradiol augments peri-infarct cerebral vascular density in experimental stroke

Agnieszka A. Ardelt, Naseem Anjum, Kiran F. Rajneesh, Piotr Kulesza, Raymond C. Koehler

Research output: Contribution to journalArticlepeer-review

Abstract

Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalExperimental Neurology
Volume206
Issue number1
DOIs
StatePublished - Jul 2007

Keywords

  • Angiogenesis
  • Estradiol
  • Infarct
  • Penumbra
  • Rat
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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