Estimation of ventricular fiber orientations in infarcted hearts for patient-specific simulations

Fijoy Vadakkumpadan, Hermenegild Arevalo, Farhad Pashakhanloo, Anthony Alers, Fady Dawoud, Karl H. Schuleri, Daniel Herzka, Elliot McVeigh, Albert C. Lardo, Natalia Trayanova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Patient-specific modeling of the heart is limited by lack of technology to acquire myocardial fiber orientations in the clinic. To overcome this limitation, we recently developed an image-based methodology to estimate the fiber orientations. In this study, we test the efficacy of that methodology in infarcted hearts. To this end, we implemented a processing pipeline to compare estimated fiber orientations of infarcted hearts with measured ones, and quantify the effect of the estimation error on outcomes of electrophysiological simulations. The pipeline was applied to images that we acquired from three infarcted canine hearts. The new insights obtained from the project will pave the way for the development of patient-specific models of infarcted hearts that can aid physicians in personalized diagnosis and decisions regarding electrophysiological interventions.

Original languageEnglish (US)
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages636-639
Number of pages4
DOIs
StatePublished - Aug 22 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Keywords

  • Physiological modeling
  • atlas-based methods
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Estimation of ventricular fiber orientations in infarcted hearts for patient-specific simulations'. Together they form a unique fingerprint.

  • Cite this

    Vadakkumpadan, F., Arevalo, H., Pashakhanloo, F., Alers, A., Dawoud, F., Schuleri, K. H., Herzka, D., McVeigh, E., Lardo, A. C., & Trayanova, N. (2013). Estimation of ventricular fiber orientations in infarcted hearts for patient-specific simulations. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 636-639). [6556555] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2013.6556555