Estimation of the area at risk in myocardial infarction of rats by means of I-123 β-methyliodophenyl pentadecanoic acid imaging

S. Hasegawa, H. Kusuoka, K. Fukuchi, M. Hori, T. Nishimura

Research output: Contribution to journalArticle

Abstract

Clinical investigations have suggested that the defects in SPECT images of a free fatty acid analog, I-123 β-methyliodophenyl pentadecanoic acid (BMIPP) may indicate the ischemic risk area. To elucidate whether I-123 BMIPP can indicate the area at risk of ischemia, ex-vivo autoradiography was performed in rats whose left coronary artery was occluded for 60 min and then reperfused. I-123 BMIPP was injected at the acute stage (n = 10), or the subacute stage (7 days after reperfusion; n = 9). Infarction and the area at risk were identified by triphenyl tetrazolium chloride staining and injection of methylene blue during religation just before sacrifice, respectively. The BMIPP uptake in the risk area was significantly lower than that in the remote area at the acute (risk, 53.7 ± 23.3% of the uptake at right ventricle, mean ± SD; remote, 109.3 ± 11.8%; p <0.01) and subacute (risk, 52.5 ± 11.5%; remote, 97.9 ± 14.3%; p <0.01) stages. In addition, the area with reduced uptake of I-123 BMIPP showed a significant correlation with the area at risk both at the acute (r = 0.98, p <0.01) and subacute (r = 0.92, p <0.01) stages. In conclusion, the area at risk can be evaluated by I-123 BMIPP both at the acute and subacute stages.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalAnnals of Nuclear Medicine
Volume14
Issue number5
StatePublished - 2000
Externally publishedYes

Fingerprint

Myocardial Infarction
pentadecanoic acid
Methylene Blue
Single-Photon Emission-Computed Tomography
Autoradiography
Nonesterified Fatty Acids
Infarction
Reperfusion
Heart Ventricles
iodofiltic acid
Chlorides
Coronary Vessels
Ischemia
Staining and Labeling
Injections

Keywords

  • Area at risk
  • BMIPP
  • Myocardial infarction
  • Reperfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Estimation of the area at risk in myocardial infarction of rats by means of I-123 β-methyliodophenyl pentadecanoic acid imaging. / Hasegawa, S.; Kusuoka, H.; Fukuchi, K.; Hori, M.; Nishimura, T.

In: Annals of Nuclear Medicine, Vol. 14, No. 5, 2000, p. 347-352.

Research output: Contribution to journalArticle

Hasegawa, S. ; Kusuoka, H. ; Fukuchi, K. ; Hori, M. ; Nishimura, T. / Estimation of the area at risk in myocardial infarction of rats by means of I-123 β-methyliodophenyl pentadecanoic acid imaging. In: Annals of Nuclear Medicine. 2000 ; Vol. 14, No. 5. pp. 347-352.
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abstract = "Clinical investigations have suggested that the defects in SPECT images of a free fatty acid analog, I-123 β-methyliodophenyl pentadecanoic acid (BMIPP) may indicate the ischemic risk area. To elucidate whether I-123 BMIPP can indicate the area at risk of ischemia, ex-vivo autoradiography was performed in rats whose left coronary artery was occluded for 60 min and then reperfused. I-123 BMIPP was injected at the acute stage (n = 10), or the subacute stage (7 days after reperfusion; n = 9). Infarction and the area at risk were identified by triphenyl tetrazolium chloride staining and injection of methylene blue during religation just before sacrifice, respectively. The BMIPP uptake in the risk area was significantly lower than that in the remote area at the acute (risk, 53.7 ± 23.3{\%} of the uptake at right ventricle, mean ± SD; remote, 109.3 ± 11.8{\%}; p <0.01) and subacute (risk, 52.5 ± 11.5{\%}; remote, 97.9 ± 14.3{\%}; p <0.01) stages. In addition, the area with reduced uptake of I-123 BMIPP showed a significant correlation with the area at risk both at the acute (r = 0.98, p <0.01) and subacute (r = 0.92, p <0.01) stages. In conclusion, the area at risk can be evaluated by I-123 BMIPP both at the acute and subacute stages.",
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