Estimation of sensitivity and specificity of site‐specific diagnostic tests

P. P. Hujoel; L. H. Moulton; W. J. Loesche

doi:10.1111/j.1600-0765.1990.tb00903.x

Estimation of sensitivity and specificity of site‐specific diagnostic tests

P. P. Hujoel, L. H. Moulton, W. J. Loesche

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site‐specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within‐patient correlation can result in an over‐ or underestimation of the true standard errors.

Original language	English (US)
Pages (from-to)	193-196
Number of pages	4
Journal	Journal of periodontal research
Volume	25
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0765.1990.tb00903.x
State	Published - Jul 1990
Externally published	Yes

ASJC Scopus subject areas

Periodontics

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10.1111/j.1600-0765.1990.tb00903.x

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title = "Estimation of sensitivity and specificity of site‐specific diagnostic tests",

abstract = "Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site‐specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within‐patient correlation can result in an over‐ or underestimation of the true standard errors.",

author = "Hujoel, {P. P.} and Moulton, {L. H.} and Loesche, {W. J.}",

year = "1990",

month = jul,

doi = "10.1111/j.1600-0765.1990.tb00903.x",

language = "English (US)",

volume = "25",

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journal = "Journal of periodontal research",

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AU - Moulton, L. H.

AU - Loesche, W. J.

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N2 - Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site‐specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within‐patient correlation can result in an over‐ or underestimation of the true standard errors.

AB - Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site‐specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within‐patient correlation can result in an over‐ or underestimation of the true standard errors.

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ER -

Estimation of sensitivity and specificity of site‐specific diagnostic tests

Abstract

ASJC Scopus subject areas

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