Estimation of pertussis vaccine efficacy in the presence of covariates in three randomized trials.

W. C. Blackwelder, M. J. VanRaden, M. A. Deloria

Research output: Contribution to journalArticlepeer-review

Abstract

We estimated efficacy of pertussis vaccines in three randomized controlled trials with adjustment for several baseline covariates: presence of one or more other children in the household, sex of the study child, and geographical area. Adjusted and unadjusted efficacy estimates differed only trivially. We also assessed the association of efficacy with time since vaccination and background pertussis incidence. The acellular vaccines, except for the two-component vaccine in the Stockholm trial, appeared to maintain their efficacy during two years of follow-up. In contrast, efficacy of a whole-cell vaccine decreased significantly in both the Stockholm and Italian trials. The relationship between efficacy and background incidence was not consistent across studies and vaccines.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalDevelopments in biological standardization
Volume89
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Drug Discovery
  • Public Health, Environmental and Occupational Health

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