Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer

Michael R. Kaus, Thomas Netsch, Sven Kabus, Vladimir Pekar, Todd McNutt, Bernd Fischer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this paper is to automatically estimate the motion of the tumor and the internal organs from 4D CT and to extract the organ surfaces. Motion induced by breathing and heart beating is an important uncertainty in conformal external beam radiotherapy (RT) of lung tumors. 4D RT aims at compensating the geometry changes during irradiation by incorporating the motion into the treatment plan using 4D CT imagery. We establish two different methods to propagate organ models through the image time series, one based on deformable surface meshes, and the other based on volumetric B-spline registration. The methods are quantitatively evaluated on 8 3D CT images of the full breathing cycle of a patient with manually segmented lungs and heart. Both methods achieve good overall results, with mean errors of 1.02-1.33 mm and 0.78-2.05 mm for deformable surfaces and B-splines respectively. The deformable mesh is fast (40 seconds vs. 50 minutes), but accommodation of the heart and the tumor is currently not possible. B-spline registration estimates the motion of all structures in the image and their interior, but is susceptible to motion artifacts in CT.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science
EditorsC. Barillot, D.R. Haynor, P. Hellier
Pages1017-1024
Number of pages8
Volume3217
Edition1 PART 2
StatePublished - 2004
Externally publishedYes
EventMedical Image Computing and Computer-Assisted Intervention, MICCAI 2004 - 7th International Conference, Proceedings - Saint-Malo, France
Duration: Sep 26 2004Sep 29 2004

Other

OtherMedical Image Computing and Computer-Assisted Intervention, MICCAI 2004 - 7th International Conference, Proceedings
CountryFrance
CitySaint-Malo
Period9/26/049/29/04

Fingerprint

Radiation Therapy
Lung Cancer
Radiotherapy
Splines
Tumors
Planning
B-spline
Motion
Tumor
Lung
Registration
Mesh
Time series
Irradiation
CT Image
3D Image
Geometry
Estimate
Interior
Internal

Keywords

  • 4D CT
  • B-splines
  • Deformable registration
  • Deformable surface models
  • Lung cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Computer Science (miscellaneous)
  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Kaus, M. R., Netsch, T., Kabus, S., Pekar, V., McNutt, T., & Fischer, B. (2004). Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer. In C. Barillot, D. R. Haynor, & P. Hellier (Eds.), Lecture Notes in Computer Science (1 PART 2 ed., Vol. 3217, pp. 1017-1024)

Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer. / Kaus, Michael R.; Netsch, Thomas; Kabus, Sven; Pekar, Vladimir; McNutt, Todd; Fischer, Bernd.

Lecture Notes in Computer Science. ed. / C. Barillot; D.R. Haynor; P. Hellier. Vol. 3217 1 PART 2. ed. 2004. p. 1017-1024.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kaus, MR, Netsch, T, Kabus, S, Pekar, V, McNutt, T & Fischer, B 2004, Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer. in C Barillot, DR Haynor & P Hellier (eds), Lecture Notes in Computer Science. 1 PART 2 edn, vol. 3217, pp. 1017-1024, Medical Image Computing and Computer-Assisted Intervention, MICCAI 2004 - 7th International Conference, Proceedings, Saint-Malo, France, 9/26/04.
Kaus MR, Netsch T, Kabus S, Pekar V, McNutt T, Fischer B. Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer. In Barillot C, Haynor DR, Hellier P, editors, Lecture Notes in Computer Science. 1 PART 2 ed. Vol. 3217. 2004. p. 1017-1024
Kaus, Michael R. ; Netsch, Thomas ; Kabus, Sven ; Pekar, Vladimir ; McNutt, Todd ; Fischer, Bernd. / Estimation of organ motion from 4D CT for 4D radiation therapy planning of lung cancer. Lecture Notes in Computer Science. editor / C. Barillot ; D.R. Haynor ; P. Hellier. Vol. 3217 1 PART 2. ed. 2004. pp. 1017-1024
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