Estimation of mercury burdens in rats by chelation with dimercaptopropane sulfonate

M. G. Cherian, E. F. Miles, T. W. Clarkson, C. Cox

Research output: Contribution to journalArticle

Abstract

The chelation of mercury by 2,3-dimercaptopropane-1-sulfonate (DMPS) and its usefulness in the estimation of mercury burdens was investigated by exposing male, Sprague-Dawley rats to 203HgCl2 (0.1-2 mg of Hg per kg i.p.) or 203Hg vapor (0.5-2.0 mg of Hg per m3). DMPS (0.2-2.0 mmol/kg) was injected i.p. at times ranging from 1 to 38 days after exposure to the mercurial. Urine and feces were collected for 24 hr before and after DMPS treatment. Whole body mercury levels, tissue levels and excretion of mercury were measured by radioactivity counting. Afting DMPS treatment there was a significant decrease of whole body mercury levels and an increase in urinary excretion. The increase in urinary excretion was directly proportional to the whole body burden of mercury at the time of dosing with DMPS in animals dosed with HgCl2 and exposed to mercury vapor. Furthermore, the increase in urinary excretion induced by DMPS was almost equal to the amount of mercury lost from the kidneys.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume245
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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