Estimation of macular pigment optical density in the elderly: Test-retest variability and effect of optical blur in pseudophakic subjects

Kevin T. Gallaher, Marco Mura, Wm Andrew Todd, Tarsha L. Harris, Emily Kenyon, Tamara Harris, Karen C. Johnson, Suzanne Satterfield, Stephen B. Kritchevsky, Alessandro Iannaccone

Research output: Contribution to journalArticlepeer-review

Abstract

The reproducibility of macular pigment optical density (MPOD) estimates in the elderly was assessed in 40 subjects (age: 79.1 ± 3.5). Test-retest variability was good (Pearson's r coefficient: 0.734), with an average coefficient of variation (CV) of 18.4% and an intraclass correlation coefficient (ICC) of 0.96. The effect of optical blur on MPOD estimates was investigated in 22 elderly pseudophakic subjects (age: 79.9 ± 3.6) by comparing the baseline MPOD, obtained with an optimal correction, with MPODs obtained with a ±1.00-diopter optical blur. This optical blur did not cause differences in the MPOD estimates, its accuracy, or test duration.

Original languageEnglish (US)
Pages (from-to)1253-1259
Number of pages7
JournalVision Research
Volume47
Issue number9
DOIs
StatePublished - Apr 2007

Keywords

  • Aging
  • Heterochromatic flicker photometry
  • Macular pigment optical density
  • Optical blur
  • Reliability

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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