TY - JOUR
T1 - Estimation of elastic moduli and bending stiffness of the anisotropic outer hair cell wall
AU - Spector, Alexander A.
AU - Brownell, William E.
AU - Popel, Aleksander S.
PY - 1998
Y1 - 1998
N2 - The outer hair cell makes both passive and active contributions to basilar membrane mechanics. The outer hair cell mechanics is strongly coupled to the elastic properties of the cell lateral wall. The lateral wall experiences both in-plane deformations and bending under physiological and experimental conditions. To characterize the outer hair cell wall, the model of an orthotopic cylindrical shell is used. The elastic constants of the wall are estimated by solving a set of three equations based on the analyses of three independent experiments. The first equation is derived from a new interpretation of the micropipet experiment; the other two are obtained from the axial loading and the osmotic challenge experiments. The two Young's moduli corresponding to the longitudinal and circumferential directions and two Poisson's ratios are estimated. The longitudinal, circumferential, and mixed modes of the bending stiffness are also estimated. The sensitivity of the derived constants to the variation of the cell axial stiffness, which has been measured by several independent groups, is examined. The new estimates are also compared with results obtained by using the assumption of the wall isotropy.
AB - The outer hair cell makes both passive and active contributions to basilar membrane mechanics. The outer hair cell mechanics is strongly coupled to the elastic properties of the cell lateral wall. The lateral wall experiences both in-plane deformations and bending under physiological and experimental conditions. To characterize the outer hair cell wall, the model of an orthotopic cylindrical shell is used. The elastic constants of the wall are estimated by solving a set of three equations based on the analyses of three independent experiments. The first equation is derived from a new interpretation of the micropipet experiment; the other two are obtained from the axial loading and the osmotic challenge experiments. The two Young's moduli corresponding to the longitudinal and circumferential directions and two Poisson's ratios are estimated. The longitudinal, circumferential, and mixed modes of the bending stiffness are also estimated. The sensitivity of the derived constants to the variation of the cell axial stiffness, which has been measured by several independent groups, is examined. The new estimates are also compared with results obtained by using the assumption of the wall isotropy.
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U2 - 10.1121/1.421217
DO - 10.1121/1.421217
M3 - Article
C2 - 9479754
AN - SCOPUS:0031885278
VL - 103
SP - 1007
EP - 1011
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
SN - 0001-4966
IS - 2
ER -