Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels

B. Sarov, L. Novack, N. Galai, A. Yaari, M. Orgel, J. Safi, V. Yahalom, E. Shinar

Research output: Contribution to journalArticlepeer-review

Abstract

Testing for anti-hepatitis C virus (HCV) antibodies in pools may reduce blood screening costs, making this approach affordable for developing countries, provided that the dilution of infected blood does not significantly increase the number of undetectable viral particles, especially in seroconverters. This study assessed the delay in detection of HCV antibodies in five HCV seroconversion panels, tested in pools of 6-48 samples, and estimated the risk of transfusion-transmitted HCV caused by pooling. The delay in detection of positive samples was 5-12 days for pools of all sizes, adding 7% to the risk of HCV transmission that occurs when blood donors' samples are tested individually.

Original languageEnglish (US)
Pages (from-to)737-739
Number of pages3
JournalClinical Microbiology and Infection
Volume13
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • Antibodies
  • Blood donors
  • Detection
  • Hepatitis C virus
  • Pooled screening
  • Seroconversion

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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