Estimation of 3D myocardial motion from tagged MRI using LDDMM

Vinay Kotamraju, Elliot McVeigh, Mirza Faisal Beg

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Non-invasive estimation of regional cardiac function is important for assessment of myocardial contractility. The use of MR tagging technique enables acquisition of intra-myocardial tissue motion by placing a spatially modulated pattern of magnetization whose deformation with the myocardium over the cardiac cycle can be imaged. Quantitative computation of parameters such as wall thickening, shearing, rotation, torsion and strain within the myocardium is traditionally achieved by processing the tag-marked MR image frames to 1) segment the tag lines and 2) detect the correspondence between points across the time-indexed frames. In this paper, we describe our approach to solving this problem using the Large Deformation Diffeomorphic Metric Mapping (LDDMM) algorithm in which tag-line segmentation and motion reconstruction occur simultaneously. Our method differs from earlier proposed non rigid registration based cardiac motion estimation methods in that our matching cost incorporates image intensity overlap via the L2 norm and the estimated tranformations are diffeomorphic. We also present a novel method of generating synthetic tag line images with known ground truth and motion characteristics that closely follow those in the original data; these can be used for validation of motion estimation algorithms. Initial validation shows that our method is able to accurately segment tag-lines and estimate a dense 3D motion field describing the motion of the myocardium in both the left and the right ventricle.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditionPART 2
StatePublished - 2007
Externally publishedYes
EventMedical Imaging 2007: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 18 2007Feb 20 2007


OtherMedical Imaging 2007: Physiology, Function, and Structure from Medical Images
Country/TerritoryUnited States
CitySan Diego, CA


  • Cardiac functional analysis
  • Computational anatomy
  • Myocardial motion estimation

ASJC Scopus subject areas

  • Engineering(all)


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