Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data

Aimee Teo Broman, Harry A Quigley, Sheila K West, Joanne Katz, Beatriz Munoz, Karen J Bandeen Roche, James M. Tielsch, David S Friedman, Jonathan Crowston, Hugh R. Taylor, Rohit Varma, M. Cristina Leske, Boel Bengtsson, Anders Heijl, Mingguang He, Paul J. Foster

Research output: Contribution to journalArticle

Abstract

PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95% CI: 8.8 -12.6) and was highest in African-derived subjects at 15.4 years (95% CI: 14.6 -15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15% or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects.

Original languageEnglish (US)
Pages (from-to)66-76
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume49
Issue number1
DOIs
StatePublished - Jan 2008

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Open Angle Glaucoma
Visual Fields
Hispanic Americans
Optic Nerve Diseases
Visual Field Tests
Population
Disease Progression
Cross-Sectional Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data. / Broman, Aimee Teo; Quigley, Harry A; West, Sheila K; Katz, Joanne; Munoz, Beatriz; Bandeen Roche, Karen J; Tielsch, James M.; Friedman, David S; Crowston, Jonathan; Taylor, Hugh R.; Varma, Rohit; Leske, M. Cristina; Bengtsson, Boel; Heijl, Anders; He, Mingguang; Foster, Paul J.

In: Investigative Ophthalmology and Visual Science, Vol. 49, No. 1, 01.2008, p. 66-76.

Research output: Contribution to journalArticle

Broman, Aimee Teo ; Quigley, Harry A ; West, Sheila K ; Katz, Joanne ; Munoz, Beatriz ; Bandeen Roche, Karen J ; Tielsch, James M. ; Friedman, David S ; Crowston, Jonathan ; Taylor, Hugh R. ; Varma, Rohit ; Leske, M. Cristina ; Bengtsson, Boel ; Heijl, Anders ; He, Mingguang ; Foster, Paul J. / Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data. In: Investigative Ophthalmology and Visual Science. 2008 ; Vol. 49, No. 1. pp. 66-76.
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abstract = "PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95{\%} CI: 8.8 -12.6) and was highest in African-derived subjects at 15.4 years (95{\%} CI: 14.6 -15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15{\%} or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects.",
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T1 - Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data

AU - Broman, Aimee Teo

AU - Quigley, Harry A

AU - West, Sheila K

AU - Katz, Joanne

AU - Munoz, Beatriz

AU - Bandeen Roche, Karen J

AU - Tielsch, James M.

AU - Friedman, David S

AU - Crowston, Jonathan

AU - Taylor, Hugh R.

AU - Varma, Rohit

AU - Leske, M. Cristina

AU - Bengtsson, Boel

AU - Heijl, Anders

AU - He, Mingguang

AU - Foster, Paul J.

PY - 2008/1

Y1 - 2008/1

N2 - PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95% CI: 8.8 -12.6) and was highest in African-derived subjects at 15.4 years (95% CI: 14.6 -15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15% or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects.

AB - PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95% CI: 8.8 -12.6) and was highest in African-derived subjects at 15.4 years (95% CI: 14.6 -15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15% or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects.

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