TY - JOUR
T1 - Estimating the cost-effectiveness of pneumococcal conjugate vaccination in Brazil
AU - Vespa, Glaucia
AU - Constenla, Dagna O.
AU - Pepe, Camila
AU - Safadi, Marco Aurélio
AU - Berezin, Eitan
AU - De Moraes, José Cássio
AU - De Campos, Carlos Alberto Herrerias
AU - Araujo, Denizar Vianna
AU - De Andrade, Ana Lucia S.S.
PY - 2009/12
Y1 - 2009/12
N2 - Objective. To compare the costs and benefits of pneumococcal conjugate vaccination compared with no vaccination from the perspectives of the health care system and society. Methods. Using data from established sources, we estimated the incidence and mortality due to invasive pneumococcal disease, pneumonia, and acute otitis media (AOM) for a hypothetical birth cohort of children from birth to 5 years. Results. A universal pneumococcal conjugate vaccination program was estimated capable of annually avoiding 1 047 cases of invasive disease, 58 226 cases of pneumonia, and 209 862 cases of AOM. When herd immunity effects were considered, the program prevented 1.3 million cases of pneumococcal disease and over 7 000 pneumococcal deaths. At a vaccination cost of R$ 51.12 (US$ 26.35) per dose, vaccination would cost annually R$ 4 289 (US$ 2, 211) per disability-adjusted life years averted. This does not take into account herd immunity effects. Conclusions. At the current vaccine price, conjugate vaccination could be a cost-effective investment compared to other options to control childhood diseases. Further analysis is required to determine whether vaccination at the current price is affordable to Brazil.
AB - Objective. To compare the costs and benefits of pneumococcal conjugate vaccination compared with no vaccination from the perspectives of the health care system and society. Methods. Using data from established sources, we estimated the incidence and mortality due to invasive pneumococcal disease, pneumonia, and acute otitis media (AOM) for a hypothetical birth cohort of children from birth to 5 years. Results. A universal pneumococcal conjugate vaccination program was estimated capable of annually avoiding 1 047 cases of invasive disease, 58 226 cases of pneumonia, and 209 862 cases of AOM. When herd immunity effects were considered, the program prevented 1.3 million cases of pneumococcal disease and over 7 000 pneumococcal deaths. At a vaccination cost of R$ 51.12 (US$ 26.35) per dose, vaccination would cost annually R$ 4 289 (US$ 2, 211) per disability-adjusted life years averted. This does not take into account herd immunity effects. Conclusions. At the current vaccine price, conjugate vaccination could be a cost-effective investment compared to other options to control childhood diseases. Further analysis is required to determine whether vaccination at the current price is affordable to Brazil.
KW - Brazil
KW - Cost efficiency analysis
KW - Pneumococcal infections
KW - Pneumococcal vaccines
KW - Streptococcus pneumoniae
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U2 - 10.1590/S1020-49892009001200007
DO - 10.1590/S1020-49892009001200007
M3 - Article
C2 - 20107706
AN - SCOPUS:77249147524
SN - 1020-4989
VL - 26
SP - 518
EP - 528
JO - Revista Panamericana de Salud Publica/Pan American Journal of Public Health
JF - Revista Panamericana de Salud Publica/Pan American Journal of Public Health
IS - 6
ER -