Estimating the cost-effectiveness of pneumococcal conjugate vaccination in Brazil

Glaucia Vespa, Dagna O. Constenla, Camila Pepe, Marco Aurélio Safadi, Eitan Berezin, José Cássio De Moraes, Carlos Alberto Herrerias De Campos, Denizar Vianna Araujo, Ana Lucia S.S. De Andrade

Research output: Contribution to journalArticlepeer-review


Objective. To compare the costs and benefits of pneumococcal conjugate vaccination compared with no vaccination from the perspectives of the health care system and society. Methods. Using data from established sources, we estimated the incidence and mortality due to invasive pneumococcal disease, pneumonia, and acute otitis media (AOM) for a hypothetical birth cohort of children from birth to 5 years. Results. A universal pneumococcal conjugate vaccination program was estimated capable of annually avoiding 1 047 cases of invasive disease, 58 226 cases of pneumonia, and 209 862 cases of AOM. When herd immunity effects were considered, the program prevented 1.3 million cases of pneumococcal disease and over 7 000 pneumococcal deaths. At a vaccination cost of R$ 51.12 (US$ 26.35) per dose, vaccination would cost annually R$ 4 289 (US$ 2, 211) per disability-adjusted life years averted. This does not take into account herd immunity effects. Conclusions. At the current vaccine price, conjugate vaccination could be a cost-effective investment compared to other options to control childhood diseases. Further analysis is required to determine whether vaccination at the current price is affordable to Brazil.

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Issue number6
StatePublished - Dec 2009
Externally publishedYes


  • Brazil
  • Cost efficiency analysis
  • Pneumococcal infections
  • Pneumococcal vaccines
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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