TY - JOUR
T1 - Estimating renal function in lupus nephritis
T2 - Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations
AU - Kasitanon, N.
AU - Fine, D. M.
AU - Haas, M.
AU - Magder, L. S.
AU - Petri, Michelle
PY - 2007
Y1 - 2007
N2 - Estimates of renal function are widely used in clinical practice and research. We assessed the performance of the Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) equations in lupus nephritis patients. Data from ninety-seven lupus nephritis patients in the Hopkins Lupus Cohort were reviewed. Two renal function estimates, the CG and the MDRD, were compared with the 24 h creatinine clearance (CrCl). In the entire group of patients, the CG and MDRD equations had good global agreement with CrCl (R-square = 0.91 and 0.69, respectively). On average the CG equation overestimated CrCl by 2.36 mL/min/1.73 m2, whereas the MDRD equation underestimated CrCl by 5.85 mL/min/1.73 m2, P = 0.0004. The CG equation had greater accuracy (mean squared error) than the MDRD equation (14.93 versus 28.47 mL/min/1.73 m2, P = 0.002) when predicting CrCl. Although both equations lacked precision (standard deviation of the difference scores) in patients with CrCl ≥ 60 mL/min/1.73 m2, the CG equation was more precise than the MDRD equation in this group, (15.68 versus 29.58 mL/min/1.73 m2, P = 0.003). In lupus nephritis patients, the CG equation was superior to the MDRD equation as an estimate of CrCl. However, both equations lacked precision in patients with CrCl ≥ 60 mL/min/1.73 m 2.
AB - Estimates of renal function are widely used in clinical practice and research. We assessed the performance of the Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) equations in lupus nephritis patients. Data from ninety-seven lupus nephritis patients in the Hopkins Lupus Cohort were reviewed. Two renal function estimates, the CG and the MDRD, were compared with the 24 h creatinine clearance (CrCl). In the entire group of patients, the CG and MDRD equations had good global agreement with CrCl (R-square = 0.91 and 0.69, respectively). On average the CG equation overestimated CrCl by 2.36 mL/min/1.73 m2, whereas the MDRD equation underestimated CrCl by 5.85 mL/min/1.73 m2, P = 0.0004. The CG equation had greater accuracy (mean squared error) than the MDRD equation (14.93 versus 28.47 mL/min/1.73 m2, P = 0.002) when predicting CrCl. Although both equations lacked precision (standard deviation of the difference scores) in patients with CrCl ≥ 60 mL/min/1.73 m2, the CG equation was more precise than the MDRD equation in this group, (15.68 versus 29.58 mL/min/1.73 m2, P = 0.003). In lupus nephritis patients, the CG equation was superior to the MDRD equation as an estimate of CrCl. However, both equations lacked precision in patients with CrCl ≥ 60 mL/min/1.73 m 2.
KW - Cockcroft-Gault
KW - Lupus nephritis
KW - Modification of diet in renal disease
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U2 - 10.1177/0961203307084167
DO - 10.1177/0961203307084167
M3 - Article
C2 - 17971362
AN - SCOPUS:36349002854
SN - 0961-2033
VL - 16
SP - 887
EP - 895
JO - Lupus
JF - Lupus
IS - 11
ER -