Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease

Noelle E. Carlozzi; Julie C. Stout; James A. Mills; Kevin Duff; Leigh J. Beglinger; Elizabeth H. Aylward; Kathryn B. Whitlock; Andrea C. Solomon; Sarah Queller; Douglas R. Langbehn; Shannon A. Johnson; Jane S. Paulsen

doi:10.1080/13854046.2011.577811

Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease

Noelle E. Carlozzi, Julie C. Stout, James A. Mills, Kevin Duff, Leigh J. Beglinger, Elizabeth H. Aylward, Kathryn B. Whitlock, Andrea C. Solomon, Sarah Queller, Douglas R. Langbehn, Shannon A. Johnson, Jane S. Paulsen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Estimates of premorbid intellect are often used in neuropsychological assessment to make inferences about cognitive decline. To optimize the method of controlling for premorbid intellect in assessments of prodromal neurodegenerative disease, we examined performance on the American National Adult Reading Test (ANART; administered during Years 1 and 3) and the two-subtest version of the Wechsler Abbreviated Scale of Intelligence (WASI; administered in Years 2 and 4) in an ongoing prospective longitudinal study of 371 participants with prodromal Huntington disease and 51 participants with normal CAG repeats. Although both measures performed similarly, the ANART demonstrated slightly lower variability in performance over a 2-year period and had slightly higher test-retest reliability than the WASI.

Original language	English (US)
Pages (from-to)	757-777
Number of pages	21
Journal	Clinical Neuropsychologist
Volume	25
Issue number	5
DOIs	https://doi.org/10.1080/13854046.2011.577811
State	Published - Jul 2011
Externally published	Yes

Keywords

Assessment
Huntington disease
Intelligence
Neuropsychological assessment
Premorbid IQ
Prodromal neurodegenerative disease

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Developmental and Educational Psychology
Arts and Humanities (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

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10.1080/13854046.2011.577811

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title = "Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease",

abstract = "Estimates of premorbid intellect are often used in neuropsychological assessment to make inferences about cognitive decline. To optimize the method of controlling for premorbid intellect in assessments of prodromal neurodegenerative disease, we examined performance on the American National Adult Reading Test (ANART; administered during Years 1 and 3) and the two-subtest version of the Wechsler Abbreviated Scale of Intelligence (WASI; administered in Years 2 and 4) in an ongoing prospective longitudinal study of 371 participants with prodromal Huntington disease and 51 participants with normal CAG repeats. Although both measures performed similarly, the ANART demonstrated slightly lower variability in performance over a 2-year period and had slightly higher test-retest reliability than the WASI.",

keywords = "Assessment, Huntington disease, Intelligence, Neuropsychological assessment, Premorbid IQ, Prodromal neurodegenerative disease",

author = "Carlozzi, {Noelle E.} and Stout, {Julie C.} and Mills, {James A.} and Kevin Duff and Beglinger, {Leigh J.} and Aylward, {Elizabeth H.} and Whitlock, {Kathryn B.} and Solomon, {Andrea C.} and Sarah Queller and Langbehn, {Douglas R.} and Johnson, {Shannon A.} and Paulsen, {Jane S.}",

note = "Funding Information: We would like to thank the National Institute of Neurological Disorders and Stroke grant # NS040068 and the High Q Foundation for the project entitled, {\textquoteleft}{\textquoteleft}Neurobiological Predictors of Huntington{\textquoteright}s Disease (PREDICT-HD).{\textquoteright}{\textquoteright} We would also like to acknowledge support from grant RR00059 from the General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health. We would like to recognize the National Research Roster for Huntington Disease Patients and Families (HD Roster) (NIH: N01 NS 3 2357) located at Indiana University School of Medicine. The HD Roster has been funded by the NIH since 1979 and serves to recruit patients and families interested in participating in HD research.",

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AU - Beglinger, Leigh J.

AU - Aylward, Elizabeth H.

AU - Whitlock, Kathryn B.

AU - Solomon, Andrea C.

AU - Queller, Sarah

AU - Langbehn, Douglas R.

AU - Johnson, Shannon A.

AU - Paulsen, Jane S.

N1 - Funding Information: We would like to thank the National Institute of Neurological Disorders and Stroke grant # NS040068 and the High Q Foundation for the project entitled, ‘‘Neurobiological Predictors of Huntington’s Disease (PREDICT-HD).’’ We would also like to acknowledge support from grant RR00059 from the General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health. We would like to recognize the National Research Roster for Huntington Disease Patients and Families (HD Roster) (NIH: N01 NS 3 2357) located at Indiana University School of Medicine. The HD Roster has been funded by the NIH since 1979 and serves to recruit patients and families interested in participating in HD research.

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Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease

Abstract

Keywords

ASJC Scopus subject areas

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