Estimating premorbid IQ in the prodromal phase of a neurodegenerative disease

Noelle E. Carlozzi, Julie C. Stout, James A. Mills, Kevin Duff, Leigh J. Beglinger, Elizabeth H. Aylward, Kathryn B. Whitlock, Andrea C. Solomon, Sarah Queller, Douglas R. Langbehn, Shannon A. Johnson, Jane S. Paulsen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Estimates of premorbid intellect are often used in neuropsychological assessment to make inferences about cognitive decline. To optimize the method of controlling for premorbid intellect in assessments of prodromal neurodegenerative disease, we examined performance on the American National Adult Reading Test (ANART; administered during Years 1 and 3) and the two-subtest version of the Wechsler Abbreviated Scale of Intelligence (WASI; administered in Years 2 and 4) in an ongoing prospective longitudinal study of 371 participants with prodromal Huntington disease and 51 participants with normal CAG repeats. Although both measures performed similarly, the ANART demonstrated slightly lower variability in performance over a 2-year period and had slightly higher test-retest reliability than the WASI.

Original languageEnglish (US)
Pages (from-to)757-777
Number of pages21
JournalClinical Neuropsychologist
Issue number5
StatePublished - Jul 2011
Externally publishedYes


  • Assessment
  • Huntington disease
  • Intelligence
  • Neuropsychological assessment
  • Premorbid IQ
  • Prodromal neurodegenerative disease

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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