Estimating platelet production in patients with HIV-related thrombocytopenia using the Immature Platelet Fraction

Brian Thomas Garibaldi, Rupal Malani, Hsin Chieh Yeh, Evan Lipson, Deborah Michell, Mosi Bennett, Alison R Moliterno, Michael A. McDevitt, Thomas Stephen Kickler

Research output: Contribution to journalArticle

Abstract

Thrombocytopenia is common in patients with HIV infection. However, given the number of potential etiologies of low-platelet counts in this patient population, it is often difficult to determine the underlying cause. The immature platelet fraction (IPF) measures the number of reticulated platelets in peripheral blood and can be used to help determine if thrombocytopenia is secondary to low-platelet production or increased platelet turnover. We studied the performance characteristics of the IPF% in 50 inpatients with HIV-related thrombocytopenia and compared the results with 34 inpatients with HIV and normal platelet counts. The mean IPF% in the HIV thrombocytopenic group was 10.2% as compared with 6.8% in the HIV normal platelet count group (P 5 0.001) and 3.1% in historical non-HIV controls (P <0.001). In multivariate analyses, the presence of ITP, active infection, log CD4 count, platelet count, and diabetes mellitus were significantly associated with a higher IPF%. These findings suggest that increased platelet turnover plays an important role in the pathogenesis of HIV thrombocytopenia. Platelet turnover is also increased in patients with HIV in general, even when overt thrombocytopenia is absent.

Original languageEnglish (US)
Pages (from-to)852-854
Number of pages3
JournalAmerican Journal of Hematology
Volume84
Issue number12
DOIs
StatePublished - Dec 2009

Fingerprint

Thrombocytopenia
Blood Platelets
HIV
Platelet Count
Inpatients
Inosine Triphosphate
CD4 Lymphocyte Count
HIV Infections
Diabetes Mellitus
Multivariate Analysis
Infection
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Estimating platelet production in patients with HIV-related thrombocytopenia using the Immature Platelet Fraction. / Garibaldi, Brian Thomas; Malani, Rupal; Yeh, Hsin Chieh; Lipson, Evan; Michell, Deborah; Bennett, Mosi; Moliterno, Alison R; McDevitt, Michael A.; Kickler, Thomas Stephen.

In: American Journal of Hematology, Vol. 84, No. 12, 12.2009, p. 852-854.

Research output: Contribution to journalArticle

@article{e6d37ee448f9478593285c3049ccd790,
title = "Estimating platelet production in patients with HIV-related thrombocytopenia using the Immature Platelet Fraction",
abstract = "Thrombocytopenia is common in patients with HIV infection. However, given the number of potential etiologies of low-platelet counts in this patient population, it is often difficult to determine the underlying cause. The immature platelet fraction (IPF) measures the number of reticulated platelets in peripheral blood and can be used to help determine if thrombocytopenia is secondary to low-platelet production or increased platelet turnover. We studied the performance characteristics of the IPF{\%} in 50 inpatients with HIV-related thrombocytopenia and compared the results with 34 inpatients with HIV and normal platelet counts. The mean IPF{\%} in the HIV thrombocytopenic group was 10.2{\%} as compared with 6.8{\%} in the HIV normal platelet count group (P 5 0.001) and 3.1{\%} in historical non-HIV controls (P <0.001). In multivariate analyses, the presence of ITP, active infection, log CD4 count, platelet count, and diabetes mellitus were significantly associated with a higher IPF{\%}. These findings suggest that increased platelet turnover plays an important role in the pathogenesis of HIV thrombocytopenia. Platelet turnover is also increased in patients with HIV in general, even when overt thrombocytopenia is absent.",
author = "Garibaldi, {Brian Thomas} and Rupal Malani and Yeh, {Hsin Chieh} and Evan Lipson and Deborah Michell and Mosi Bennett and Moliterno, {Alison R} and McDevitt, {Michael A.} and Kickler, {Thomas Stephen}",
year = "2009",
month = "12",
doi = "10.1002/ajh.21559",
language = "English (US)",
volume = "84",
pages = "852--854",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "12",

}

TY - JOUR

T1 - Estimating platelet production in patients with HIV-related thrombocytopenia using the Immature Platelet Fraction

AU - Garibaldi, Brian Thomas

AU - Malani, Rupal

AU - Yeh, Hsin Chieh

AU - Lipson, Evan

AU - Michell, Deborah

AU - Bennett, Mosi

AU - Moliterno, Alison R

AU - McDevitt, Michael A.

AU - Kickler, Thomas Stephen

PY - 2009/12

Y1 - 2009/12

N2 - Thrombocytopenia is common in patients with HIV infection. However, given the number of potential etiologies of low-platelet counts in this patient population, it is often difficult to determine the underlying cause. The immature platelet fraction (IPF) measures the number of reticulated platelets in peripheral blood and can be used to help determine if thrombocytopenia is secondary to low-platelet production or increased platelet turnover. We studied the performance characteristics of the IPF% in 50 inpatients with HIV-related thrombocytopenia and compared the results with 34 inpatients with HIV and normal platelet counts. The mean IPF% in the HIV thrombocytopenic group was 10.2% as compared with 6.8% in the HIV normal platelet count group (P 5 0.001) and 3.1% in historical non-HIV controls (P <0.001). In multivariate analyses, the presence of ITP, active infection, log CD4 count, platelet count, and diabetes mellitus were significantly associated with a higher IPF%. These findings suggest that increased platelet turnover plays an important role in the pathogenesis of HIV thrombocytopenia. Platelet turnover is also increased in patients with HIV in general, even when overt thrombocytopenia is absent.

AB - Thrombocytopenia is common in patients with HIV infection. However, given the number of potential etiologies of low-platelet counts in this patient population, it is often difficult to determine the underlying cause. The immature platelet fraction (IPF) measures the number of reticulated platelets in peripheral blood and can be used to help determine if thrombocytopenia is secondary to low-platelet production or increased platelet turnover. We studied the performance characteristics of the IPF% in 50 inpatients with HIV-related thrombocytopenia and compared the results with 34 inpatients with HIV and normal platelet counts. The mean IPF% in the HIV thrombocytopenic group was 10.2% as compared with 6.8% in the HIV normal platelet count group (P 5 0.001) and 3.1% in historical non-HIV controls (P <0.001). In multivariate analyses, the presence of ITP, active infection, log CD4 count, platelet count, and diabetes mellitus were significantly associated with a higher IPF%. These findings suggest that increased platelet turnover plays an important role in the pathogenesis of HIV thrombocytopenia. Platelet turnover is also increased in patients with HIV in general, even when overt thrombocytopenia is absent.

UR - http://www.scopus.com/inward/record.url?scp=73349136748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349136748&partnerID=8YFLogxK

U2 - 10.1002/ajh.21559

DO - 10.1002/ajh.21559

M3 - Article

VL - 84

SP - 852

EP - 854

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 12

ER -