Estimating incidence rates using exact or interval-censored data with an application to hospital-acquired infections

Lisha Deng, Peter J. Diggle, John Cheesbrough

Research output: Contribution to journalArticle

Abstract

Health-care providers in the UK and elsewhere are required to maintain records of incidents relating to patient safety, including the date and time of each incident. However, for reporting and analysis, the resulting data are typically grouped into discrete time intervals, for example, weekly or monthly counts. The grouping represents a potential loss of information for estimating variations in incidence over time. We use a Poisson point process model to quantify this loss of information. We also suggest some diagnostic procedures for checking the goodness of fit of the Poisson model. Finally, we apply the model to the data on hospital-acquired methicillin-resistant Staphylococcus aureus infections in two hospitals in the north of England. We find that, in one of the hospitals, the estimated incidence decreased by a factor of approximately 2.3 over a 7-year period from 0.323 to 0.097 cases per day per 1000 beds, whereas in the other, the estimated incidence showed only a small and nonsignificant decrease over the same period from 0.137 to 0.131.

Original languageEnglish (US)
Pages (from-to)963-977
Number of pages15
JournalStatistics in Medicine
Volume31
Issue number10
DOIs
StatePublished - May 10 2012
Externally publishedYes

Fingerprint

Interval-censored Data
Cross Infection
Infection
Incidence
Poisson Point Process
Poisson Model
Patient Safety
Methicillin-Resistant Staphylococcus aureus
Goodness of fit
Date
England
Grouping
Health Personnel
Healthcare
Process Model
Diagnostics
Count
Discrete-time
Quantify
Safety

Keywords

  • Hospital-acquired infection
  • Log-linear model
  • MRSA
  • Patient safety
  • Point process
  • Poisson process

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

Cite this

Estimating incidence rates using exact or interval-censored data with an application to hospital-acquired infections. / Deng, Lisha; Diggle, Peter J.; Cheesbrough, John.

In: Statistics in Medicine, Vol. 31, No. 10, 10.05.2012, p. 963-977.

Research output: Contribution to journalArticle

Deng, Lisha ; Diggle, Peter J. ; Cheesbrough, John. / Estimating incidence rates using exact or interval-censored data with an application to hospital-acquired infections. In: Statistics in Medicine. 2012 ; Vol. 31, No. 10. pp. 963-977.
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