Estimate of Plasmodium falciparum sporozoite content of Anopheles stephensi used to challenge human volunteers

J. R. Davis; J. R. Murphy; D. F. Clyde; S. Baqar; A. H. Cochrane; F. Zavala; R. S. Nussenzweig

doi:10.4269/ajtmh.1989.40.128

Estimate of Plasmodium falciparum sporozoite content of Anopheles stephensi used to challenge human volunteers

J. R. Davis, J. R. Murphy, D. F. Clyde, S. Baqar, A. H. Cochrane, F. Zavala, R. S. Nussenzweig

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Plasmodium falciparum infected Anopheles stephensi, taken from a group of mosquitoes which had been used to challenge recipients of (NANP)₃-TT vaccine, were tested for P. falciparum sporozoite content by an immunoradiometric assay. Seventy-six percent were infected with mean and median sporozoite equivalents per mosquito of 220,994 and 217,398, respectively (SD = 54,911). This sporozoite density is greater than that usually found in the field. These data suggest that this challenge for evaluating P. falciparum sporozoite vaccines is a demanding test of immunity.

Original language	English (US)
Pages (from-to)	128-130
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	40
Issue number	2
DOIs	https://doi.org/10.4269/ajtmh.1989.40.128
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Virology
Infectious Diseases

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10.4269/ajtmh.1989.40.128

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title = "Estimate of Plasmodium falciparum sporozoite content of Anopheles stephensi used to challenge human volunteers",

abstract = "Plasmodium falciparum infected Anopheles stephensi, taken from a group of mosquitoes which had been used to challenge recipients of (NANP)3-TT vaccine, were tested for P. falciparum sporozoite content by an immunoradiometric assay. Seventy-six percent were infected with mean and median sporozoite equivalents per mosquito of 220,994 and 217,398, respectively (SD = 54,911). This sporozoite density is greater than that usually found in the field. These data suggest that this challenge for evaluating P. falciparum sporozoite vaccines is a demanding test of immunity.",

author = "Davis, {J. R.} and Murphy, {J. R.} and Clyde, {D. F.} and S. Baqar and Cochrane, {A. H.} and F. Zavala and Nussenzweig, {R. S.}",

year = "1989",

doi = "10.4269/ajtmh.1989.40.128",

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T1 - Estimate of Plasmodium falciparum sporozoite content of Anopheles stephensi used to challenge human volunteers

AU - Davis, J. R.

AU - Murphy, J. R.

AU - Clyde, D. F.

AU - Baqar, S.

AU - Cochrane, A. H.

AU - Zavala, F.

AU - Nussenzweig, R. S.

PY - 1989

Y1 - 1989

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AB - Plasmodium falciparum infected Anopheles stephensi, taken from a group of mosquitoes which had been used to challenge recipients of (NANP)3-TT vaccine, were tested for P. falciparum sporozoite content by an immunoradiometric assay. Seventy-six percent were infected with mean and median sporozoite equivalents per mosquito of 220,994 and 217,398, respectively (SD = 54,911). This sporozoite density is greater than that usually found in the field. These data suggest that this challenge for evaluating P. falciparum sporozoite vaccines is a demanding test of immunity.

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Estimate of Plasmodium falciparum sporozoite content of Anopheles stephensi used to challenge human volunteers

Abstract

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