Barbara A. Murphy, Salyka Sengsayadeth, Joseph M. Aulino, Christine H. Chung, Kim Ely, Robert J. Sinard, Anthony J. Cmelak

Research output: Chapter in Book/Report/Conference proceedingChapter


Esthesioneuroblastoma, also termed olfactory neuroblastoma, is a rare malignancy of neural crest origin, which comprises about 6% of nasal cavity and paranasal sinuses tumors. First described by Berger and Luc in 1924, more than 1400 cases have since been reported in the literature. The neoplasm develops from the olfactory epithelium of the cribriform plate, the superior upper one-third of the nasal septum, and the upper surface of the superior turbinate, and has a propensity to invade the skull base and intracranial space. Esthesioneuroblastoma has been known by many names including esthesioneurocytoma, olfactory intranasal neuroblastoma, esthesioneuroepithelioma, olfactory esthesioneuroma, tumor of olfactory placode, and neuroolfactory tumor. The rarity of this tumor has led to the slow progress in our understanding of its pathobiology and the lack of consensus regarding treatment.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer
PublisherJohn Wiley and Sons
Number of pages12
ISBN (Print)9781118083734
StatePublished - Sep 20 2012


  • Electron microscopy
  • Esthesioneuroblastoma
  • Molecular biology
  • Nodal disease
  • Radiation therapy
  • Recurrent disease
  • Regional and distant disease
  • Resectable disease
  • Staging system
  • Surgical management
  • Unresectable disease

ASJC Scopus subject areas

  • Medicine(all)


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