Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner, Stefan Cano, Maria C. Carrillo, Ola Selnes, Yaakov Stern, Ronald G. Thomas, John Zajicek, Jeremy Hobart

Research output: Contribution to journalArticle


The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
Issue number1 SUPPL.
StatePublished - Feb 2013



  • ADAS-Cog
  • ADNI
  • Alzheimer's disease
  • Cognition
  • MCI
  • Neuropsychology
  • Psychometric

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

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