Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner; Stefan Cano; Maria C. Carrillo; Ola Selnes; Yaakov Stern; Ronald G. Thomas; John Zajicek; Jeremy Hobart

doi:10.1016/j.jalz.2012.10.008

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner, Stefan Cano, Maria C. Carrillo, Ola Selnes, Yaakov Stern, Ronald G. Thomas, John Zajicek, Jeremy Hobart

Bloomberg School of Public Health

Research output: Contribution to journal › Article

Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original language	English (US)
Journal	Alzheimer's and Dementia
Volume	9
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1016/j.jalz.2012.10.008
State	Published - Feb 2013

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Keywords

ADAS-Cog
ADNI
Alzheimer's disease
Cognition
MCI
Neuropsychology
Psychometric

ASJC Scopus subject areas

Health Policy
Epidemiology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Developmental Neuroscience
Clinical Neurology

Cite this

Posner, H. B., Cano, S., Carrillo, M. C., Selnes, O., Stern, Y., Thomas, R. G., Zajicek, J., & Hobart, J. (2013). Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach. Alzheimer's and Dementia, 9(1 SUPPL.). https://doi.org/10.1016/j.jalz.2012.10.008

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors : A new approach. / Posner, Holly B.; Cano, Stefan; Carrillo, Maria C.; Selnes, Ola; Stern, Yaakov; Thomas, Ronald G.; Zajicek, John; Hobart, Jeremy.

In: Alzheimer's and Dementia, Vol. 9, No. 1 SUPPL., 02.2013.

Research output: Contribution to journal › Article

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10.1016/j.jalz.2012.10.008