TY - JOUR
T1 - Establishing the optimal nebulization system for paclitaxel, docetaxel, cisplatin, carboplatin and gemcitabine
T2 - Back to drawing the residual cup
AU - Zarogoulidis, Paul
AU - Petridis, Dimitris
AU - Ritzoulis, Christos
AU - Darwiche, Kaid
AU - Spyratos, Dionysis
AU - Huang, Haidong
AU - Goldberg, Eugene P.
AU - Yarmus, Lonny
AU - Li, Qiang
AU - Freitag, Lutz
AU - Zarogoulidis, Konstantinos
PY - 2013
Y1 - 2013
N2 - Background: Chemotherapy drugs have still the major disadvantage of non-specific cytotoxic effects. Although, new drugs targeting the genome of the tumor are already in the market, doublet chemotherapy regimens still remain the cornerstone of lung cancer treatment. Novel modalities of administration are under investigation such as; aerosol, intratumoral and intravascular. Materials and methods: In the present study five chemotherapy drugs; paclitaxel, docetaxel, gemcitabine, carboplatin and cisplatin were nebulized with three different jet nebulizers (Maxineb®, Sunmist®, Invacare®) and six different residual cups at different concentrations. The purpose of the study was to identify the "ideal" combination of nebulizer-residual cup design-drug-drug loading for a future concept of aerosol chemotherapy in lung cancer patients. The Mastersizer® 2000 was used to evaluate the aerosol droplet mass median aerodynamic diameter. Results: The drug, nebulizer and residual cup design greatly influences the producing droplet size (p < 0.005, in each case). However; the design of the residual cup is the most important factor affecting the produced droplet size (F = 834.6, p < 0.001). The drug loading plays a vital role in the production of the desired droplet size (F = 10.42, p < 0.001). The smallest droplet size was produced at 8 ml loading (1.26 μm), while it remained the same at 2, 4 and 6 mls of drug loading. Conclusion: The ideal nebulizer would be Maxineb®, with a large residual cup (10 ml maximum loading capacity) and 8 mls loading and the drug with efficient pulmonary deposition would be docetaxel.
AB - Background: Chemotherapy drugs have still the major disadvantage of non-specific cytotoxic effects. Although, new drugs targeting the genome of the tumor are already in the market, doublet chemotherapy regimens still remain the cornerstone of lung cancer treatment. Novel modalities of administration are under investigation such as; aerosol, intratumoral and intravascular. Materials and methods: In the present study five chemotherapy drugs; paclitaxel, docetaxel, gemcitabine, carboplatin and cisplatin were nebulized with three different jet nebulizers (Maxineb®, Sunmist®, Invacare®) and six different residual cups at different concentrations. The purpose of the study was to identify the "ideal" combination of nebulizer-residual cup design-drug-drug loading for a future concept of aerosol chemotherapy in lung cancer patients. The Mastersizer® 2000 was used to evaluate the aerosol droplet mass median aerodynamic diameter. Results: The drug, nebulizer and residual cup design greatly influences the producing droplet size (p < 0.005, in each case). However; the design of the residual cup is the most important factor affecting the produced droplet size (F = 834.6, p < 0.001). The drug loading plays a vital role in the production of the desired droplet size (F = 10.42, p < 0.001). The smallest droplet size was produced at 8 ml loading (1.26 μm), while it remained the same at 2, 4 and 6 mls of drug loading. Conclusion: The ideal nebulizer would be Maxineb®, with a large residual cup (10 ml maximum loading capacity) and 8 mls loading and the drug with efficient pulmonary deposition would be docetaxel.
KW - Chemotherapy
KW - Lung cancer
KW - Nebulizers
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U2 - 10.1016/j.ijpharm.2013.06.011
DO - 10.1016/j.ijpharm.2013.06.011
M3 - Article
C2 - 23769993
AN - SCOPUS:84884159887
SN - 0378-5173
VL - 453
SP - 480
EP - 487
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 2
ER -