Establishing a bone marrow stromal cell transplant program at the national institutes of health clinical center

David F. Stroncek, Marianna Sabatino, Jiaqiang Ren, Lee England, Sergei A. Kuznetsov, Harvey G. Klein, Pamela G. Robey

Research output: Contribution to journalArticle

Abstract

A repository of cryopreserved bone marrow stromal cell (BMSC) products prepared from marrow aspirates of healthy subjects has been created and is being used to treat patients with inflammatory bowel disease, cardiovascular disease, and acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. New methods of manufacturing BMSCs are being investigated including the use of an automated bioreactor for BMSC expansion and the replacement of fetal bovine serum with human platelet lysate as a media supplement. Efforts are also being made to identify markers that can be used to assess the potency of BMSCs.

Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalTissue Engineering - Part B: Reviews
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

Fingerprint

Transplants
National Institutes of Health (U.S.)
Mesenchymal Stromal Cells
Bone
Health
Hematopoietic Stem Cell Transplantation
Bioreactors
Graft vs Host Disease
Inflammatory Bowel Diseases
Healthy Volunteers
Cardiovascular Diseases
Blood Platelets
Bone Marrow
Platelets
Stem cells
Grafts
Serum

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Biochemistry
  • Medicine(all)

Cite this

Stroncek, D. F., Sabatino, M., Ren, J., England, L., Kuznetsov, S. A., Klein, H. G., & Robey, P. G. (2014). Establishing a bone marrow stromal cell transplant program at the national institutes of health clinical center. Tissue Engineering - Part B: Reviews, 20(3), 200-205. https://doi.org/10.1089/ten.teb.2013.0529

Establishing a bone marrow stromal cell transplant program at the national institutes of health clinical center. / Stroncek, David F.; Sabatino, Marianna; Ren, Jiaqiang; England, Lee; Kuznetsov, Sergei A.; Klein, Harvey G.; Robey, Pamela G.

In: Tissue Engineering - Part B: Reviews, Vol. 20, No. 3, 01.06.2014, p. 200-205.

Research output: Contribution to journalArticle

Stroncek, David F. ; Sabatino, Marianna ; Ren, Jiaqiang ; England, Lee ; Kuznetsov, Sergei A. ; Klein, Harvey G. ; Robey, Pamela G. / Establishing a bone marrow stromal cell transplant program at the national institutes of health clinical center. In: Tissue Engineering - Part B: Reviews. 2014 ; Vol. 20, No. 3. pp. 200-205.
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