Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015

L. Galluzzi, J. M. Bravo-San Pedro, I. Vitale, S. A. Aaronson, J. M. Abrams, D. Adam, E. S. Alnemri, L. Altucci, D. Andrews, M. Annicchiarico-Petruzzelli, E. H. Baehrecke, N. G. Bazan, M. J. Bertrand, K. Bianchi, M. V. Blagosklonny, K. Blomgren, C. Borner, D. E. Bredesen, C. Brenner, M. CampanellaE. Candi, F. Cecconi, F. K. Chan, N. S. Chandel, E. H. Cheng, J. E. Chipuk, J. A. Cidlowski, A. Ciechanover, Ted M Dawson, Valina Dawson, V. De Laurenzi, R. De Maria, K. M. Debatin, N. Di Daniele, V. M. Dixit, B. D. Dynlacht, W. S. El-Deiry, G. M. Fimia, R. A. Flavell, S. Fulda, C. Garrido, M. L. Gougeon, D. R. Green, H. Gronemeyer, G. Hajnoczky, J Marie Hardwick, M. O. Hengartner, H. Ichijo, B. Joseph, P. J. Jost, T. Kaufmann, O. Kepp, D. J. Klionsky, R. A. Knight, S. Kumar, J. J. Lemasters, B. Levine, A. Linkermann, S. A. Lipton, R. A. Lockshin, C. López-Otín, E. Lugli, F. Madeo, W. Malorni, J. C. Marine, S. J. Martin, J. C. Martinou, J. P. Medema, P. Meier, S. Melino, N. Mizushima, U. Moll, C. Muñoz-Pinedo, G. Nuñez, A. Oberst, T. Panaretakis, J. M. Penninger, M. E. Peter, M. Piacentini, P. Pinton, J. H. Prehn, H. Puthalakath, G. A. Rabinovich, K. S. Ravichandran, R. Rizzuto, C. M. Rodrigues, D. C. Rubinsztein, T. Rudel, Y. Shi, H. U. Simon, B. R. Stockwell, G. Szabadkai, S. W. Tait, Ho Lam Tang, N. Tavernarakis, Y. Tsujimoto, T. Vanden Berghe, P. Vandenabeele, A. Villunger, E. F. Wagner, H. Walczak, E. White, W. G. Wood, J. Yuan, Z. Zakeri, B. Zhivotovsky, G. Melino, G. Kroemer

Research output: Contribution to journalArticle

Abstract

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

Original languageEnglish (US)
Pages (from-to)58-73
Number of pages16
JournalCell Death and Differentiation
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2015

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Cell Death
Biochemical Phenomena
Genetic Engineering
Cytoprotection
Caspases
Terminology
Signal Transduction
Research Personnel
Apoptosis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., ... Kroemer, G. (2015). Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), 58-73. https://doi.org/10.1038/cdd.2014.137

Essential versus accessory aspects of cell death : Recommendations of the NCCD 2015. / Galluzzi, L.; Bravo-San Pedro, J. M.; Vitale, I.; Aaronson, S. A.; Abrams, J. M.; Adam, D.; Alnemri, E. S.; Altucci, L.; Andrews, D.; Annicchiarico-Petruzzelli, M.; Baehrecke, E. H.; Bazan, N. G.; Bertrand, M. J.; Bianchi, K.; Blagosklonny, M. V.; Blomgren, K.; Borner, C.; Bredesen, D. E.; Brenner, C.; Campanella, M.; Candi, E.; Cecconi, F.; Chan, F. K.; Chandel, N. S.; Cheng, E. H.; Chipuk, J. E.; Cidlowski, J. A.; Ciechanover, A.; Dawson, Ted M; Dawson, Valina; De Laurenzi, V.; De Maria, R.; Debatin, K. M.; Di Daniele, N.; Dixit, V. M.; Dynlacht, B. D.; El-Deiry, W. S.; Fimia, G. M.; Flavell, R. A.; Fulda, S.; Garrido, C.; Gougeon, M. L.; Green, D. R.; Gronemeyer, H.; Hajnoczky, G.; Hardwick, J Marie; Hengartner, M. O.; Ichijo, H.; Joseph, B.; Jost, P. J.; Kaufmann, T.; Kepp, O.; Klionsky, D. J.; Knight, R. A.; Kumar, S.; Lemasters, J. J.; Levine, B.; Linkermann, A.; Lipton, S. A.; Lockshin, R. A.; López-Otín, C.; Lugli, E.; Madeo, F.; Malorni, W.; Marine, J. C.; Martin, S. J.; Martinou, J. C.; Medema, J. P.; Meier, P.; Melino, S.; Mizushima, N.; Moll, U.; Muñoz-Pinedo, C.; Nuñez, G.; Oberst, A.; Panaretakis, T.; Penninger, J. M.; Peter, M. E.; Piacentini, M.; Pinton, P.; Prehn, J. H.; Puthalakath, H.; Rabinovich, G. A.; Ravichandran, K. S.; Rizzuto, R.; Rodrigues, C. M.; Rubinsztein, D. C.; Rudel, T.; Shi, Y.; Simon, H. U.; Stockwell, B. R.; Szabadkai, G.; Tait, S. W.; Tang, Ho Lam; Tavernarakis, N.; Tsujimoto, Y.; Vanden Berghe, T.; Vandenabeele, P.; Villunger, A.; Wagner, E. F.; Walczak, H.; White, E.; Wood, W. G.; Yuan, J.; Zakeri, Z.; Zhivotovsky, B.; Melino, G.; Kroemer, G.

In: Cell Death and Differentiation, Vol. 22, No. 1, 01.01.2015, p. 58-73.

Research output: Contribution to journalArticle

Galluzzi, L, Bravo-San Pedro, JM, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Alnemri, ES, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, EH, Bazan, NG, Bertrand, MJ, Bianchi, K, Blagosklonny, MV, Blomgren, K, Borner, C, Bredesen, DE, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, FK, Chandel, NS, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Dawson, TM, Dawson, V, De Laurenzi, V, De Maria, R, Debatin, KM, Di Daniele, N, Dixit, VM, Dynlacht, BD, El-Deiry, WS, Fimia, GM, Flavell, RA, Fulda, S, Garrido, C, Gougeon, ML, Green, DR, Gronemeyer, H, Hajnoczky, G, Hardwick, JM, Hengartner, MO, Ichijo, H, Joseph, B, Jost, PJ, Kaufmann, T, Kepp, O, Klionsky, DJ, Knight, RA, Kumar, S, Lemasters, JJ, Levine, B, Linkermann, A, Lipton, SA, Lockshin, RA, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, JC, Martin, SJ, Martinou, JC, Medema, JP, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, JM, Peter, ME, Piacentini, M, Pinton, P, Prehn, JH, Puthalakath, H, Rabinovich, GA, Ravichandran, KS, Rizzuto, R, Rodrigues, CM, Rubinsztein, DC, Rudel, T, Shi, Y, Simon, HU, Stockwell, BR, Szabadkai, G, Tait, SW, Tang, HL, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, EF, Walczak, H, White, E, Wood, WG, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G & Kroemer, G 2015, 'Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015', Cell Death and Differentiation, vol. 22, no. 1, pp. 58-73. https://doi.org/10.1038/cdd.2014.137
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D et al. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015. Cell Death and Differentiation. 2015 Jan 1;22(1):58-73. https://doi.org/10.1038/cdd.2014.137
Galluzzi, L. ; Bravo-San Pedro, J. M. ; Vitale, I. ; Aaronson, S. A. ; Abrams, J. M. ; Adam, D. ; Alnemri, E. S. ; Altucci, L. ; Andrews, D. ; Annicchiarico-Petruzzelli, M. ; Baehrecke, E. H. ; Bazan, N. G. ; Bertrand, M. J. ; Bianchi, K. ; Blagosklonny, M. V. ; Blomgren, K. ; Borner, C. ; Bredesen, D. E. ; Brenner, C. ; Campanella, M. ; Candi, E. ; Cecconi, F. ; Chan, F. K. ; Chandel, N. S. ; Cheng, E. H. ; Chipuk, J. E. ; Cidlowski, J. A. ; Ciechanover, A. ; Dawson, Ted M ; Dawson, Valina ; De Laurenzi, V. ; De Maria, R. ; Debatin, K. M. ; Di Daniele, N. ; Dixit, V. M. ; Dynlacht, B. D. ; El-Deiry, W. S. ; Fimia, G. M. ; Flavell, R. A. ; Fulda, S. ; Garrido, C. ; Gougeon, M. L. ; Green, D. R. ; Gronemeyer, H. ; Hajnoczky, G. ; Hardwick, J Marie ; Hengartner, M. O. ; Ichijo, H. ; Joseph, B. ; Jost, P. J. ; Kaufmann, T. ; Kepp, O. ; Klionsky, D. J. ; Knight, R. A. ; Kumar, S. ; Lemasters, J. J. ; Levine, B. ; Linkermann, A. ; Lipton, S. A. ; Lockshin, R. A. ; López-Otín, C. ; Lugli, E. ; Madeo, F. ; Malorni, W. ; Marine, J. C. ; Martin, S. J. ; Martinou, J. C. ; Medema, J. P. ; Meier, P. ; Melino, S. ; Mizushima, N. ; Moll, U. ; Muñoz-Pinedo, C. ; Nuñez, G. ; Oberst, A. ; Panaretakis, T. ; Penninger, J. M. ; Peter, M. E. ; Piacentini, M. ; Pinton, P. ; Prehn, J. H. ; Puthalakath, H. ; Rabinovich, G. A. ; Ravichandran, K. S. ; Rizzuto, R. ; Rodrigues, C. M. ; Rubinsztein, D. C. ; Rudel, T. ; Shi, Y. ; Simon, H. U. ; Stockwell, B. R. ; Szabadkai, G. ; Tait, S. W. ; Tang, Ho Lam ; Tavernarakis, N. ; Tsujimoto, Y. ; Vanden Berghe, T. ; Vandenabeele, P. ; Villunger, A. ; Wagner, E. F. ; Walczak, H. ; White, E. ; Wood, W. G. ; Yuan, J. ; Zakeri, Z. ; Zhivotovsky, B. ; Melino, G. ; Kroemer, G. / Essential versus accessory aspects of cell death : Recommendations of the NCCD 2015. In: Cell Death and Differentiation. 2015 ; Vol. 22, No. 1. pp. 58-73.
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abstract = "Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.",
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T1 - Essential versus accessory aspects of cell death

T2 - Recommendations of the NCCD 2015

AU - Galluzzi, L.

AU - Bravo-San Pedro, J. M.

AU - Vitale, I.

AU - Aaronson, S. A.

AU - Abrams, J. M.

AU - Adam, D.

AU - Alnemri, E. S.

AU - Altucci, L.

AU - Andrews, D.

AU - Annicchiarico-Petruzzelli, M.

AU - Baehrecke, E. H.

AU - Bazan, N. G.

AU - Bertrand, M. J.

AU - Bianchi, K.

AU - Blagosklonny, M. V.

AU - Blomgren, K.

AU - Borner, C.

AU - Bredesen, D. E.

AU - Brenner, C.

AU - Campanella, M.

AU - Candi, E.

AU - Cecconi, F.

AU - Chan, F. K.

AU - Chandel, N. S.

AU - Cheng, E. H.

AU - Chipuk, J. E.

AU - Cidlowski, J. A.

AU - Ciechanover, A.

AU - Dawson, Ted M

AU - Dawson, Valina

AU - De Laurenzi, V.

AU - De Maria, R.

AU - Debatin, K. M.

AU - Di Daniele, N.

AU - Dixit, V. M.

AU - Dynlacht, B. D.

AU - El-Deiry, W. S.

AU - Fimia, G. M.

AU - Flavell, R. A.

AU - Fulda, S.

AU - Garrido, C.

AU - Gougeon, M. L.

AU - Green, D. R.

AU - Gronemeyer, H.

AU - Hajnoczky, G.

AU - Hardwick, J Marie

AU - Hengartner, M. O.

AU - Ichijo, H.

AU - Joseph, B.

AU - Jost, P. J.

AU - Kaufmann, T.

AU - Kepp, O.

AU - Klionsky, D. J.

AU - Knight, R. A.

AU - Kumar, S.

AU - Lemasters, J. J.

AU - Levine, B.

AU - Linkermann, A.

AU - Lipton, S. A.

AU - Lockshin, R. A.

AU - López-Otín, C.

AU - Lugli, E.

AU - Madeo, F.

AU - Malorni, W.

AU - Marine, J. C.

AU - Martin, S. J.

AU - Martinou, J. C.

AU - Medema, J. P.

AU - Meier, P.

AU - Melino, S.

AU - Mizushima, N.

AU - Moll, U.

AU - Muñoz-Pinedo, C.

AU - Nuñez, G.

AU - Oberst, A.

AU - Panaretakis, T.

AU - Penninger, J. M.

AU - Peter, M. E.

AU - Piacentini, M.

AU - Pinton, P.

AU - Prehn, J. H.

AU - Puthalakath, H.

AU - Rabinovich, G. A.

AU - Ravichandran, K. S.

AU - Rizzuto, R.

AU - Rodrigues, C. M.

AU - Rubinsztein, D. C.

AU - Rudel, T.

AU - Shi, Y.

AU - Simon, H. U.

AU - Stockwell, B. R.

AU - Szabadkai, G.

AU - Tait, S. W.

AU - Tang, Ho Lam

AU - Tavernarakis, N.

AU - Tsujimoto, Y.

AU - Vanden Berghe, T.

AU - Vandenabeele, P.

AU - Villunger, A.

AU - Wagner, E. F.

AU - Walczak, H.

AU - White, E.

AU - Wood, W. G.

AU - Yuan, J.

AU - Zakeri, Z.

AU - Zhivotovsky, B.

AU - Melino, G.

AU - Kroemer, G.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

AB - Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

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DO - 10.1038/cdd.2014.137

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