Abstract
Background: V-ATPase is responsible for establishing electrochemical gradients through energy-dependent proton transport. Results: In Candida albicans, mutation of vph1 resulted in defective phenotypic switching and avirulence in a murine septicemia model. Conclusion: The vacuolar specific isoform Vph1 is essential for vacuolar acidification and virulence in Candida albicans. Significance: Acidification of the vacuole plays a unique role in fungal virulence and growth phenotype.
Original language | English (US) |
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Pages (from-to) | 26256-26264 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 36 |
DOIs | |
State | Published - Sep 6 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology