Essential role for vacuolar acidification in candida albicans virulence

Cassandra Patenaude, Yongqiang Zhang, Brendan Cormack, Julia Köhler, Rajini Rao

Research output: Contribution to journalArticlepeer-review

Abstract

Background: V-ATPase is responsible for establishing electrochemical gradients through energy-dependent proton transport. Results: In Candida albicans, mutation of vph1 resulted in defective phenotypic switching and avirulence in a murine septicemia model. Conclusion: The vacuolar specific isoform Vph1 is essential for vacuolar acidification and virulence in Candida albicans. Significance: Acidification of the vacuole plays a unique role in fungal virulence and growth phenotype.

Original languageEnglish (US)
Pages (from-to)26256-26264
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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