Essential role for vacuolar acidification in candida albicans virulence

Cassandra Patenaude; Yongqiang Zhang; Brendan Cormack; Julia Köhler; Rajini Rao

doi:10.1074/jbc.M113.494815

Essential role for vacuolar acidification in candida albicans virulence

Cassandra Patenaude, Yongqiang Zhang, Brendan Cormack, Julia Köhler, Rajini Rao

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: V-ATPase is responsible for establishing electrochemical gradients through energy-dependent proton transport. Results: In Candida albicans, mutation of vph1 resulted in defective phenotypic switching and avirulence in a murine septicemia model. Conclusion: The vacuolar specific isoform Vph1 is essential for vacuolar acidification and virulence in Candida albicans. Significance: Acidification of the vacuole plays a unique role in fungal virulence and growth phenotype.

Original language	English (US)
Pages (from-to)	26256-26264
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.494815
State	Published - Sep 6 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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AU - Patenaude, Cassandra

AU - Zhang, Yongqiang

AU - Cormack, Brendan

AU - Köhler, Julia

AU - Rao, Rajini

PY - 2013/9/6

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AB - Background: V-ATPase is responsible for establishing electrochemical gradients through energy-dependent proton transport. Results: In Candida albicans, mutation of vph1 resulted in defective phenotypic switching and avirulence in a murine septicemia model. Conclusion: The vacuolar specific isoform Vph1 is essential for vacuolar acidification and virulence in Candida albicans. Significance: Acidification of the vacuole plays a unique role in fungal virulence and growth phenotype.

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