Escitalopram, but not its major metabolites, exhibits antiplatelet activity in humans

Dan Atar, Alex Malinin, Aviv Takserman, Alex Pokov, Louis Van Zyl, Jean Francois Tanguay, Francois Lesperance, Victor Serebruany

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Clinical depression has been identified as an independent risk factor for increased mortality during follow-up in patients suffered from acute coronary events, while increased platelet activity has been proposed as one of the mechanisms for this association. Some evidence suggests that selective serotonin reuptalce inhibitors and/or their metabolites exhibit potent antiplatelet properties. Methods: We assessed the in vitro effects of preincubation with escalating (50-200 nmol/L) concentrations of escitalopram (ESC), S-desmethyl-citalopram (S-DCT), and S-di-desmethyl-citalopram (S-DDCT) on platelet aggregation, expression of major surface receptors by flow cytometry and quantitatively by platelet function analyzers in 20 healthy volunteers. Results: Pretreatment of blood samples with ESC resulted in a significant inhibition of platelet aggregation induced by ADP (P = 0.0001) and by collagen with the highest dose (P = 0001). Surface platelet expression of glycoprotein Ib (CD42) (P = 0.04), lysosome associated membrane protein-3 (CD63) (P = 0.02), and GP37 (CD165) (P = 0.03) was decreased in the ESC-pretreated samples. Closure time by the Platelet Function Analyzer-100 analyzer was prolonged for the 200 nmol/L dose (P = 0.02) indicating platelet inhibition under high shear conditions. Two major metabolites of ESC, namely S-DCT and S-DDCT, did not affect platelet activity. Conclusion: Escitalopram, but not its metabolites, exhibited in vitro selective inhibition of human platelets. The direct antiplatelet effects of ESC requires further prospective ex vivo testing to determine the potential clinical advantage of this finding.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume26
Issue number2
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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